(Q40586989)

21 September 2017

title

Peptide-based, irreversible inhibitors of gamma-secretase activity (English)

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21 September 2017

Siân C Piper

1

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21 September 2017

Zareen Amtul

2

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21 September 2017

Laura Galiñanes-Garcia

3

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21 September 2017

Victor G Howard

4

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21 September 2017

Chewki Ziani-Cherif

5

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21 September 2017

Chris McLendon

6

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21 September 2017

Marjorie J Rochette

7

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21 September 2017

Abdul Fauq

8

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21 September 2017

Todd E Golde

9

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21 September 2017

M Paul Murphy

10

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21 September 2017

publication date

1 June 2003

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Biochemical and Biophysical Research Communications

21 September 2017

published in

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21 September 2017

volume

305

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21 September 2017

issue

3

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21 September 2017

page(s)

529-533

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Alzheimer's disease: genes, proteins, and therapy

21 September 2017

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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

7 January 2021

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7 January 2021

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

7 January 2021

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Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

7 January 2021

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Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Nicastrin binds to membrane-tethered Notch

7 January 2021

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Haloperidol-based irreversible inhibitors of the HIV-1 and HIV-2 proteases

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

7 January 2021

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FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants

7 January 2021

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Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

7 January 2021

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A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

7 January 2021

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

7 January 2021

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A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production

7 January 2021

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

7 January 2021

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

7 January 2021

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Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

7 January 2021

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The role of presenilin cofactors in the gamma-secretase complex

7 January 2021

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10.1016/S0006-291X(03)00828-3

7 January 2021

Identifiers

DOI

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21 September 2017

1 reference