(Q44188224)

30 November 2017

Gamma-secretase: substrates and inhibitors (English)

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30 November 2017

Marjorie J Rochette

1

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PubMed ID

12392058

30 November 2017

M Paul Murphy

series ordinal

2

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30 November 2017

1 August 2002

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30 November 2017

Molecular Neurobiology

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30 November 2017

26

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30 November 2017

1

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30 November 2017

81-95

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https://scigraph.springernature.com/pub.10.1385/mn:26:1:081

30 November 2017

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cites work

Signalling downstream of activated mammalian Notch

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12 December 2020

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

12 December 2020

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

1 reference

12 December 2020

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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12 December 2020

Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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12 December 2020

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

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12 December 2020

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

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12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

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12 December 2020

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

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12 December 2020

Alzheimer's disease: the amyloid cascade hypothesis

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12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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12 December 2020

Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein

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12 December 2020

Gamma -secretase inhibitors repress thymocyte development

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12 December 2020

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

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12 December 2020

The multiple paradoxes of presenilins

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12 December 2020

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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12 December 2020

LIN-12/Notch signaling: lessons from worms and flies

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12 December 2020

Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis

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12 December 2020

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

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12 December 2020

Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR.

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12 December 2020

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

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12 December 2020

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

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12 December 2020

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

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12 December 2020

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

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12 December 2020

Presenilin-dependent gamma-secretase activity modulates thymocyte development

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12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

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12 December 2020

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

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12 December 2020

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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12 December 2020

Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease

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12 December 2020

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

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12 December 2020

Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins

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12 December 2020

Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha

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12 December 2020

Pathological proteins in senile plaques.

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12 December 2020

Notch signaling: cell fate control and signal integration in development

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12 December 2020

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

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12 December 2020

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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12 December 2020

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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12 December 2020

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

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12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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12 December 2020

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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12 December 2020

Neuropathological stageing of Alzheimer-related changes

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12 December 2020

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

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12 December 2020

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

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12 December 2020

Participation of gene expression in the protection against amyloid beta-peptide toxicity by the beta-amyloid precursor protein.

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12 December 2020

Presenilins and the intramembrane proteolysis of proteins: facts and fiction.

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12 December 2020

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

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12 December 2020

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

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12 December 2020

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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12 December 2020

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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12 December 2020

Cell-free assays for gamma-secretase activity

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12 December 2020

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

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12 December 2020

Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle

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12 December 2020

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

Erbb4 and its isoforms: selective regulation of growth factor responses by naturally occurring receptor variants.

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12 December 2020

Binding partners of Alzheimer's disease proteins: are they physiologically relevant?

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12 December 2020

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

An empirical model of gamma-secretase activity

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12 December 2020

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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12 December 2020

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

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12 December 2020

Presenilins as therapeutic targets for the treatment of Alzheimer's disease

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12 December 2020

A portrait of Alzheimer secretases--new features and familiar faces

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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12 December 2020

Presenilin is required for activity and nuclear access of Notch in Drosophila

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12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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12 December 2020

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

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12 December 2020

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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12 December 2020

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

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12 December 2020

Three types of amyloid protein precursor mRNA in human brain: their differential expression in Alzheimer's disease

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12 December 2020

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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12 December 2020

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

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12 December 2020

Constitutive proteolysis of the ErbB-4 receptor tyrosine kinase by a unique, sequential mechanism.

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12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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12 December 2020

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

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12 December 2020

Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides

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12 December 2020

Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations

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12 December 2020

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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12 December 2020

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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12 December 2020

Amyloid, the presenilins and Alzheimer's disease

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12 December 2020

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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12 December 2020

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

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12 December 2020

A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production

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12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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12 December 2020

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

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12 December 2020

FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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12 December 2020

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

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12 December 2020

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

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12 December 2020

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

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12 December 2020

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

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12 December 2020

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

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12 December 2020

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

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12 December 2020

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

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12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

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12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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12 December 2020

Identifiers

DOI

10.1385/MN:26:1:081

1 reference

PubMed ID

12392058

Dimensions Publication ID

30 November 2017

0 references

1 reference

PubMed ID

12392058