(Q40615439)

22 September 2017

title

Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction (English)

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22 September 2017

2

Angel Cedazo-Minguez

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22 September 2017

5

Bengt Winblad

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22 September 2017

Bogdan O Popescu

1

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22 September 2017

Eirikur Benedikz

3

1 reference

22 September 2017

Takeshi Nishimura

4

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22 September 2017

Maria Ankarcrona

6

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22 September 2017

Richard F Cowburn

7

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22 September 2017

language of work or name

English

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publication date

18 November 2003

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Journal of Biological Chemistry

22 September 2017

published in

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22 September 2017

volume

279

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22 September 2017

issue

8

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22 September 2017

page(s)

6455-6464

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

22 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M306041200

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Alzheimer's disease and Abeta toxicity: from top to bottom

21 January 2018

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Neurons bearing presenilins: weapons for defense or suicide?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.

21 January 2018

1 reference

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Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

21 January 2018

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Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimer's disease

21 January 2018

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Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

21 January 2018

1 reference

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Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation

21 January 2018

1 reference

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Calcium ionophore increases amyloid beta peptide production by cultured cells

21 January 2018

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Neuronal calcium signaling

21 January 2018

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Phospholipase C isozymes selectively couple to specific neurotransmitter receptors

21 January 2018

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Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

21 January 2018

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Apolipoprotein E isoform-specific disruption of phosphoinositide hydrolysis: protection by estrogen and glutathione

21 January 2018

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Calsenilin reverses presenilin-mediated enhancement of calcium signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M306041200

Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity

21 January 2018

1 reference

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic beta-amyloid pathology known as 'cotton wool' plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Cell surface expression of the Alzheimer disease-related presenilin proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

Contribution of presenilin/gamma-secretase to calsenilin-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306041200

21 January 2018

Identifiers

DOI

10.1074/JBC.M306041200

1 reference

22 September 2017

1 reference