(Q40659209)

22 September 2017

1 reference

title

beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload (English)

1 reference

ineffective erythropoiesis

22 September 2017

1 reference

1 reference

1 reference

3

1 reference

22 September 2017

Luca Melchiori

1

1 reference

22 September 2017

Sara Gardenghi

series ordinal

2

1 reference

22 September 2017

19 May 2010

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22 September 2017

Advances in Hematology

1 reference

22 September 2017

2010

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22 September 2017

938640

1 reference

Creative Commons Attribution 3.0 Unported

22 September 2017

start time

1 January 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling

22 September 2017

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Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

22 September 2017

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Ineffective erythropoiesis and thalassemias

22 September 2017

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Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.

22 September 2017

1 reference

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Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

22 September 2017

1 reference

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Foxo3 is required for the regulation of oxidative stress in erythropoiesis

22 September 2017

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Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

22 September 2017

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EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts

22 September 2017

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TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

22 September 2017

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The molecular mechanism of hepcidin-mediated ferroportin down-regulation

22 September 2017

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Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

22 September 2017

1 reference

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BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors

22 September 2017

1 reference

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Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera.

22 September 2017

1 reference

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Suppression of hepcidin during anemia requires erythropoietic activity

22 September 2017

1 reference

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Interleukin-6 induces hepcidin expression through STAT3

22 September 2017

1 reference

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Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

22 September 2017

1 reference

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Erythroblastic islands: specialized microenvironmental niches for erythropoiesis

22 September 2017

1 reference

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Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis

22 September 2017

1 reference

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Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia

22 September 2017

1 reference

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Comparative studies of duodenal and macrophage ferroportin proteins.

22 September 2017

1 reference

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Identification of an acquired JAK2 mutation in polycythemia vera

22 September 2017

1 reference

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

22 September 2017

1 reference

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

22 September 2017

1 reference

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Turning cells red: signal transduction mediated by erythropoietin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Hepcidin in iron overload disorders

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Balancing acts: molecular control of mammalian iron metabolism

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Pathophysiology of thalassemia

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

The hypercoagulable state in thalassemia

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Chelation therapy in beta-thalassemia: an optimistic update

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Signal transduction in the erythropoietin receptor system

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Erythropoietin receptor: cloning strategy and structural features

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells).

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Asymptomatic brain magnetic resonance imaging abnormalities in splenectomized adults with thalassemia intermedia.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Stroke in thalassemia: a dilemma.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Functional p85alpha gene is required for normal murine fetal erythropoiesis

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

Ineffective erythropoiesis in beta-thalassemia major is due to apoptosis at the polychromatophilic normoblast stage.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with beta-thalassemia major.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873658

mRNA expression of iron regulatory genes in β-thalassemia intermedia and β-thalassemia major mouse models

1 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20508726

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Decreased hepcidin mRNA expression in thalassemic mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20508726

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2010/938640

1 reference

release_ljkfs3ikbfd55p4t4mzuf7pbbe

22 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ljkfs3ikbfd55p4t4mzuf7pbbe

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

22 September 2017

PubMed publication ID

20508726

1 reference