(Q40715731)

23 September 2017

Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program (English)

1 reference

23 September 2017

1 reference

Louie Lamorte

1

1 reference

23 September 2017

Sonia Rodrigues

series ordinal

2

1 reference

23 September 2017

Monica Naujokas

series ordinal

3

1 reference

23 September 2017

Morag Park

series ordinal

4

1 reference

23 September 2017

language of work or name

English

0 references

publication date

23 July 2002

1 reference

Journal of Biological Chemistry

23 September 2017

1 reference

23 September 2017

277

1 reference

23 September 2017

37904-37911

1 reference

23 September 2017

40

1 reference

23 September 2017

Epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Molecular cloning and expression of human hepatocyte growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Scatter factor induces blood vessel formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Differential effects of EGF and amphiregulin on adhesion molecule expression and migration of colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Gab3, a new DOS/Gab family member, facilitates macrophage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Crk family adaptors-signalling complex formation and biological roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Motility and invasion are differentially modulated by Rho family GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Physiological signals and oncogenesis mediated through Crk family adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and sustained activation of the Ras/mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Hepatocyte growth factor induces tubulogenesis of primary renal proximal tubular epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Rac1 mediates type I collagen-dependent MMP-2 activation. role in cell invasion across collagen barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

21 January 2018

Identifiers

DOI

10.1074/JBC.M201743200

1 reference

23 September 2017

1 reference