(Q40742576)

23 September 2017

title

Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23. (English)

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23 September 2017

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spinocerebellar ataxia

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Anna Duarri

4

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Georgy Bakalkin

object named as

Georgy Bakalkin

12

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Harm H Kampinga

object named as

Harm H Kampinga

13

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Jan M van Deursen

11

object named as

Jan van Deursen

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23 September 2017

Cleo J L M Smeets

1

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23 September 2017

Justyna Jezierska

2

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23 September 2017

Hiroyuki Watanabe

3

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23 September 2017

Michiel R Fokkens

5

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23 September 2017

Michel Meijer

6

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23 September 2017

Qin Zhou

7

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23 September 2017

Tania Yakovleva

8

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23 September 2017

Erik Boddeke

9

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23 September 2017

Wilfred den Dunnen

10

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23 September 2017

Bart van de Sluis

14

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23 September 2017

Dineke S Verbeek

15

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23 September 2017

language of work or name

English

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publication date

12 July 2015

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23 September 2017

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23 September 2017

volume

138

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23 September 2017

issue

Pt 9

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23 September 2017

page(s)

2537-2552

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Endogenous Opioids: Biology and Function

23 September 2017

cites work

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV195

Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23.

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Membrane interaction of disease-related dynorphin A variants

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Dynorphin--still an extraordinarily potent opioid peptide

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Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum

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Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7

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Identification of cell types from action potential waveforms: cerebellar granule cells.

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Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment

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Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

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Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging.

21 January 2018

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Ablation of glutamate receptor GluRδ2 in adult Purkinje cells causes multiple innervation of climbing fibers by inducing aberrant invasion to parallel fiber innervation territory.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.

21 January 2018

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Dynorphin A (1-17) induces apoptosis in striatal neurons in vitro through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor-mediated cytochrome c release and caspase-3 activation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Identifiers

DOI

10.1093/BRAIN/AWV195

1 reference

23 September 2017

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