(Q40744440)

23 September 2017

title

TGF-beta1 acts as a tumor suppressor of human malignant keratinocytes independently of Smad 4 expression and ligand-induced G(1) arrest (English)

1 reference

23 September 2017

Ian C Paterson

1

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23 September 2017

Maria Davies

2

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23 September 2017

Andrea Stone

3

1 reference

23 September 2017

Suzy Huntley

4

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23 September 2017

Emily Smith

5

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23 September 2017

Miranda Pring

6

1 reference

23 September 2017

John W Eveson

7

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23 September 2017

C Max Robinson

8

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23 September 2017

E Kenneth Parkinson

9

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23 September 2017

Stephen S Prime

10

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23 September 2017

language of work or name

English

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publication date

1 February 2002

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23 September 2017

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23 September 2017

volume

21

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23 September 2017

issue

10

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23 September 2017

page(s)

1616-1624

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205217

23 September 2017

exact match

0 references

cites work

Expression of a dominant negative type II TGF-beta receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Novel inactivating mutations of transforming growth factor-beta type I receptor gene in head-and-neck cancer metastases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Overexpression of autocrine TGF-beta 1 suppresses the growth of spindle epithelial cells in vitro and in vivo in the rat 4NQO model of oral carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Role of transforming growth factor-beta signaling in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Smads: transcriptional activators of TGF-beta responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Cancer-susceptibility genes. Gatekeepers and caretakers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Expression of Smad proteins in human colorectal cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Identification of two Smad4 proteins in Xenopus. Their common and distinct properties

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Decreased expression of TGF-beta cell surface receptors during progression of human oral squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Effects of transforming growth factor beta-1 on growth-regulatory genes in tumour-derived human oral keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

TGF-beta receptor regulation mediates the response to exogenous ligand but is independent of the degree of cellular differentiation in human oral keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Ras gene point mutation is a rare event in premalignant tissues and malignant cells and tissues from oral mucosal lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Human Smad3 and Smad4 are sequence-specific transcription activators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205217

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205217

1 reference

Dimensions Publication ID

23 September 2017

1034579683

0 references

1 reference