(Q40863253)

24 September 2017

title

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro (English)

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24 September 2017

13

Donald E Ingber

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24 September 2017

Kambez H Benam

1

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24 September 2017

Remi Villenave

2

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24 September 2017

Carolina Lucchesi

3

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24 September 2017

Antonio Varone

4

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24 September 2017

Cedric Hubeau

5

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24 September 2017

Hyun-Hee Lee

6

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24 September 2017

Stephen E Alves

7

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24 September 2017

Michael Salmon

8

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24 September 2017

Thomas C Ferrante

9

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24 September 2017

James C Weaver

10

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24 September 2017

Anthony Bahinski

11

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24 September 2017

Geraldine A Hamilton

12

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24 September 2017

publication date

21 December 2015

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24 September 2017

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24 September 2017

volume

13

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24 September 2017

issue

2

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24 September 2017

page(s)

151-157

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https://scigraph.springernature.com/pub.10.1038/nmeth.3697

24 September 2017

exact match

0 references

cites work

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The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives

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Macrophages are required for dendritic cell uptake of respiratory syncytial virus from an infected epithelium

21 January 2018

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Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.

21 January 2018

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House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

21 January 2018

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Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection

21 January 2018

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Leukocyte-endothelial interactions in inflammation

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Microfluidic organs-on-chips.

21 January 2018

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Organs-on-chips at the frontiers of drug discovery

21 January 2018

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A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice

21 January 2018

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Reconstituting organ-level lung functions on a chip

21 January 2018

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Mucociliary clearance in the airways

21 January 2018

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When cilia go bad: cilia defects and ciliopathies

21 January 2018

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Cystic fibrosis and other respiratory diseases of impaired mucus clearance

21 January 2018

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Interleukin-13 in asthma pathogenesis

21 January 2018

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Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

21 January 2018

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Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung

21 January 2018

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Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression

21 January 2018

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Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma.

21 January 2018

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Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cells

21 January 2018

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Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells

21 January 2018

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Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells

21 January 2018

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Bronchial epithelial spheroids: an alternative culture model to investigate epithelium inflammation-mediated COPD.

21 January 2018

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The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia

21 January 2018

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Glucocorticoid insensitivity as a source of drug targets for respiratory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3697

BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNMETH.3697

E-selectin supports neutrophil rolling in vitro under conditions of flow

21 January 2018

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Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway

21 January 2018

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Interleukin-6 neutralization alleviates pulmonary inflammation in mice exposed to cigarette smoke and poly(I:C).

21 January 2018

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A biomimetic multicellular model of the airways using primary human cells.

21 January 2018

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Cell number and distribution in human and rat airways

21 January 2018

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https://api.crossref.org/works/10.1038%2FNMETH.3697

In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FNMETH.3697

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3697

Alternative spliced CD1d transcripts in human bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3697

Evidence that proteases are involved in superoxide production by human polymorphonuclear leukocytes and monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3697

Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3697

Number and proliferation of clara cells in normal human airway epithelium

21 January 2018

1 reference

12 December 2020

Neutrophils roll on E-selectin

1 reference

12 December 2020

Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells

1 reference

12 December 2020

Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids

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12 December 2020

Well-differentiated human airway epithelial cell cultures.

1 reference

12 December 2020

Severe childhood asthma: a common international approach?

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12 December 2020

Severity of airflow limitation is associated with severity of airway inflammation in smokers

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12 December 2020

Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1

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12 December 2020

Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis

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12 December 2020

Identifiers

DOI

10.1038/NMETH.3697

1 reference

24 September 2017

1 reference