(Q51510970)

6 April 2018

title

Microfluidic organs-on-chips. (English)

1 reference

6 April 2018

0 references

2

Donald E Ingber

1 reference

6 April 2018

1

Sangeeta N Bhatia

1 reference

6 April 2018

publication date

1 August 2014

1 reference

6 April 2018

published in

Nature Biotechnology

1 reference

6 April 2018

volume

32

1 reference

6 April 2018

issue

8

1 reference

6 April 2018

page(s)

760-772

1 reference

6 April 2018

https://scigraph.springernature.com/pub.10.1038/nbt.2989

exact match

0 references

cites work

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

1 reference

12 December 2020

In vitro zonation and toxicity in a hepatocyte bioreactor

1 reference

12 December 2020

Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model

1 reference

12 December 2020

Probing functional properties of nociceptive axons using a microfluidic culture system.

1 reference

12 December 2020

Muscle on a chip: in vitro contractility assays for smooth and striated muscle

1 reference

12 December 2020

Murine in vitro model of the blood-brain barrier for evaluating drug transport

1 reference

12 December 2020

Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform.

1 reference

12 December 2020

Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip

1 reference

12 December 2020

Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS.

1 reference

12 December 2020

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips.

1 reference

12 December 2020

Patient-specific 3D microfluidic tissue model for multiple myeloma

1 reference

12 December 2020

1 reference

12 December 2020

Patterning proteins and cells using soft lithography

1 reference

12 December 2020

Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats

1 reference

12 December 2020

Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems

1 reference

12 December 2020

Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments

1 reference

12 December 2020

In vitro model of tumor cell extravasation.

1 reference

12 December 2020

Simultaneous generation of gradients with gradually changed slope in a microfluidic device for quantifying axon response

1 reference

12 December 2020

A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice

1 reference

12 December 2020

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

1 reference

12 December 2020

Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures

1 reference

12 December 2020

Neuromuscular junction in a microfluidic device.

1 reference

12 December 2020

Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers

1 reference

12 December 2020

Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane).

1 reference

12 December 2020

Clear castable polyurethane elastomer for fabrication of microfluidic devices

1 reference

12 December 2020

Analysis of transcriptomic and proteomic profiles demonstrates improved Madin-Darby canine kidney cell function in a renal microfluidic biochip

1 reference

12 December 2020

Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells

1 reference

12 December 2020

Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip

1 reference

12 December 2020

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

1 reference

12 December 2020

Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts

1 reference

12 December 2020

Subcellular positioning of small molecules

1 reference

12 December 2020

Fabrication of two-layered channel system with embedded electrodes to measure resistance across epithelial and endothelial barriers.

1 reference

12 December 2020

Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system

1 reference

12 December 2020

Mechanobiology and developmental control

1 reference

12 December 2020

Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments

1 reference

12 December 2020

Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells

1 reference

12 December 2020

Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues

1 reference

12 December 2020

A biophysical indicator of vaso-occlusive risk in sickle cell disease

1 reference

12 December 2020

Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications

1 reference

12 December 2020

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

1 reference

12 December 2020

TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling

1 reference

12 December 2020

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

1 reference

12 December 2020

In vitro analysis of a hepatic device with intrinsic microvascular-based channels.

1 reference

12 December 2020

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure

1 reference

12 December 2020

A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease

1 reference

12 December 2020

A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip

1 reference

12 December 2020

Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac

1 reference

12 December 2020

Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane).

1 reference

12 December 2020

Microfluidic heart on a chip for higher throughput pharmacological studies

1 reference

12 December 2020

A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

1 reference

12 December 2020

A microfluidic device designed to induce media flow throughout pancreatic islets while limiting shear-induced damage.

1 reference

12 December 2020

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

1 reference

12 December 2020

Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure

1 reference

12 December 2020

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

1 reference

12 December 2020

Non-invasive microfluidic gap junction assay

1 reference

12 December 2020

In vitro electrical-stimulated wound-healing chip for studying electric field-assisted wound-healing process

1 reference

12 December 2020

Cellular micropatterns on biocompatible materials

1 reference

12 December 2020

Reconstituting organ-level lung functions on a chip

1 reference

12 December 2020

A microfluidic array for quantitative analysis of human neural stem cell self-renewal and differentiation in three-dimensional hypoxic microenvironment

1 reference

12 December 2020

Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture

1 reference

12 December 2020

A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax

1 reference

12 December 2020

Metabolic discrimination of select list agents by monitoring cellular responses in a multianalyte microphysiometer

1 reference

12 December 2020

An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture

1 reference

12 December 2020

Systematic reviews of animal models: methodology versus epistemology

1 reference

12 December 2020

A modular approach to create a neurovascular unit-on-a-chip

1 reference

12 December 2020

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow.

1 reference

12 December 2020

Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

1 reference

12 December 2020

Perfused multiwell plate for 3D liver tissue engineering

1 reference

12 December 2020

The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors

1 reference

12 December 2020

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB).

1 reference

12 December 2020

The outgrowth of the nerve fiber as a mode of protoplasmic movement

1 reference

12 December 2020

Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers.

1 reference

12 December 2020

Chip-based comparison of the osteogenesis of human bone marrow- and adipose tissue-derived mesenchymal stem cells under mechanical stimulation

1 reference

12 December 2020

A microfluidic 3D hepatocyte chip for drug toxicity testing.

1 reference

12 December 2020

Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes

1 reference

12 December 2020

Microfluidic Cardiac Cell Culture Model (μCCCM)

1 reference

12 December 2020

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

1 reference

12 December 2020

Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells

1 reference

12 December 2020

Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems

1 reference

12 December 2020

Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices

1 reference

12 December 2020

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion.

1 reference

12 December 2020

Integrating biological vasculature into a multi-organ-chip microsystem

1 reference

12 December 2020

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic 'body-on-a-chip' devices.

1 reference

12 December 2020

Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro.

1 reference

12 December 2020

A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays

1 reference

12 December 2020

Electrofluidic pressure sensor embedded microfluidic device: a study of endothelial cells under hydrostatic pressure and shear stress combinations

1 reference

12 December 2020

Micropatterned three-dimensional hydrogel system to study human endothelial-mesenchymal stem cell interactions

1 reference

12 December 2020

The growth of cells on a transparent gel of reconstituted rat-tail collagen

1 reference

12 December 2020

Formation of steady-state oxygen gradients in vitro: application to liver zonation

1 reference

12 December 2020

Cerebral organoids model human brain development and microcephaly

1 reference

12 December 2020

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans

1 reference

12 December 2020

Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling

1 reference

12 December 2020

Microfluidic chip with integrated electrical cell-impedance sensing for monitoring single cancer cell migration in three-dimensional matrixes

1 reference

12 December 2020

Geometric control of cell life and death

1 reference

12 December 2020

The effect of astrocytes on the induction of barrier properties in aortic endothelial cells

1 reference

12 December 2020

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance.

1 reference

12 December 2020

In vitro perfused human capillary networks

1 reference

12 December 2020

Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells.

1 reference

12 December 2020

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

1 reference

12 December 2020

Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling

1 reference

12 December 2020

A microfluidic microelectrode array for simultaneous electrophysiology, chemical stimulation, and imaging of brain slices

1 reference

12 December 2020

Characterization of microfluidic human epidermal keratinocyte culture

1 reference

12 December 2020

Three-dimensional extracellular matrix-mediated neural stem cell differentiation in a microfluidic device.

1 reference

12 December 2020

Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells

1 reference

12 December 2020

Pulmonary tissue engineering using dual-compartment polymer scaffolds with integrated vascular tree.

1 reference

12 December 2020

Mechanobiology and diseases of mechanotransduction

1 reference

12 December 2020

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

1 reference

12 December 2020

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

1 reference

12 December 2020

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

1 reference

12 December 2020

Muscular thin films for building actuators and powering devices.

1 reference

12 December 2020

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

1 reference

12 December 2020

Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance

1 reference

12 December 2020

Human neural stem cell growth and differentiation in a gradient-generating microfluidic device

1 reference

12 December 2020

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

1 reference

12 December 2020

Mechanisms of tumor cell extravasation in an in vitro microvascular network platform

1 reference

12 December 2020

Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients

1 reference

12 December 2020

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.

1 reference

12 December 2020

Patterning osteogenesis by inducible gene expression in microfluidic culture systems.

1 reference

12 December 2020

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells.

1 reference

12 December 2020

Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and Its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips

1 reference

12 December 2020

Identification of small molecules for human hepatocyte expansion and iPS differentiation

1 reference

12 December 2020

Study on invadopodia formation for lung carcinoma invasion with a microfluidic 3D culture device

1 reference

12 December 2020

BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function.

1 reference

12 December 2020

High-throughput combinatorial cell co-culture using microfluidics

1 reference

12 December 2020

Efficient Generation of Schwann Cells from Human Embryonic Stem Cell-Derived Neurospheres

1 reference

12 December 2020

Metabolic characterization of primary rat hepatocytes cultivated in parallel microfluidic biochips.

1 reference

12 December 2020

Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device

1 reference

12 December 2020

Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes

1 reference

12 December 2020

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

1 reference

12 December 2020

A microfluidic cell culture array with various oxygen tensions

1 reference

12 December 2020

Engineering cell shape and function

1 reference

12 December 2020

Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs.

1 reference

12 December 2020

A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues

1 reference

12 December 2020

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

1 reference

12 December 2020

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

1 reference

12 December 2020

Ischemia/reperfusion injury of primary porcine cardiomyocytes in a low-shear microfluidic culture and analysis device

1 reference

12 December 2020

Multiplexed, high-throughput analysis of 3D microtissue suspensions

1 reference

12 December 2020

Tissue engineering the mechanosensory circuit of the stretch reflex arc: sensory neuron innervation of intrafusal muscle fibers

1 reference

12 December 2020

Three-dimensional cultures of mouse mammary epithelial cells

1 reference

12 December 2020

Development of a renal microchip for in vitro distal tubule models.

1 reference

12 December 2020

Microscale culture of human liver cells for drug development.

1 reference

12 December 2020

A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils.

1 reference

12 December 2020

A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells

1 reference

12 December 2020

A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

1 reference

12 December 2020

Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments

1 reference

12 December 2020

Scaling and systems biology for integrating multiple organs-on-a-chip

1 reference

12 December 2020

Skeletal muscle atrophy in bioengineered skeletal muscle: a new model system

1 reference

12 December 2020

Hormonally responsive breast cancer cells in a microfluidic co-culture model as a sensor of microenvironmental activity.

1 reference

12 December 2020

Molding of deep polydimethylsiloxane microstructures for microfluidics and biological applications

1 reference

12 December 2020

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels

1 reference

12 December 2020

A microfluidic platform for probing small artery structure and function

1 reference

12 December 2020

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

1 reference

12 December 2020

Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies

1 reference

12 December 2020

Engineering challenges for instrumenting and controlling integrated organ-on-chip systems

1 reference

12 December 2020

Idiosyncratic drug hepatotoxicity

1 reference

12 December 2020

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NBT.2989

1 reference

6 April 2018

Dimensions Publication ID

1040859225

0 references

1 reference

6 April 2018