(Q42716716)

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Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and Its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 November 2017

Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and Its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips (English)

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Europe PubMed Central

PubMed publication ID

5 November 2017

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Bénédicte Elena-Herrmann

object named as

Bénédicte Elena-Herrmann

7

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Cécile Legallais

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Cécile Legallais

4

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author name string

Leila Choucha Snouber

1

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Europe PubMed Central

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5 November 2017

Andrei Bunescu

2

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Europe PubMed Central

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5 November 2017

Marie Naudot

3

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Europe PubMed Central

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5 November 2017

Céline Brochot

5

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Europe PubMed Central

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5 November 2017

Marc Emmanuel Dumas

6

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Europe PubMed Central

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5 November 2017

Eric Leclerc

8

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5 November 2017

publication date

27 July 2012

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Europe PubMed Central

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5 November 2017

Toxicological Sciences

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5 November 2017

132

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PubMed publication ID

5 November 2017

1

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5 November 2017

8-20

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5 November 2017

describes a project that uses

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Flutamide-induced hepatic dysfunction in relation to steady-state plasma concentrations of flutamide and its metabolites

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Metabotyping of Caenorhabditis elegans reveals latent phenotypes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Bioactivation and hepatotoxicity of nitroaromatic drugs

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues

1 reference

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21 January 2018

Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry

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alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Bioactivation of flutamide metabolites by human liver microsomes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Metabolic footprinting and systems biology: the medium is the message

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Cells for bioartificial liver devices: the human hepatoma-derived cell line C3A produces urea but does not detoxify ammonia

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose-binding site of the human erythrocyte glucose transporter GLUT1.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Metabonomics: a platform for studying drug toxicity and gene function

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

5-Oxoproline reduces non-enzymatic antioxidant defenses in vitro in rat brain.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Improvement of HepG2/C3a cell functions in a microfluidic biochip

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

The pharmacokinetics of flutamide and its major metabolites after a single oral dose and during chronic treatment

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs.

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

A microfluidic 3D hepatocyte chip for drug toxicity testing.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Induction of 5-oxoprolinuria in the rat following chronic feeding with N -acetyl 4-aminophenol (paracetamol)

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Global metabolic profiling procedures for urine using UPLC–MS

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS230

21 January 2018

Identifiers

10.1093/TOXSCI/KFS230

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

ResearchGate publication ID

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