(Q40871201)

English

Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines

scientific article published on June 2000

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scholarly article

1 reference

Europe PubMed Central

24 September 2017

Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines (English)

1 reference

Europe PubMed Central

24 September 2017

author name string

H Edamatsu

1

1 reference

Europe PubMed Central

24 September 2017

C L Gau

2

1 reference

Europe PubMed Central

24 September 2017

T Nemoto

3

1 reference

Europe PubMed Central

24 September 2017

L Guo

4

1 reference

Europe PubMed Central

24 September 2017

F Tamanoi

5

1 reference

Europe PubMed Central

24 September 2017

language of work or name

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publication date

1 June 2000

1 reference

Europe PubMed Central

24 September 2017

1 reference

Europe PubMed Central

24 September 2017

19

1 reference

Europe PubMed Central

24 September 2017

3059-3068

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Europe PubMed Central

24 September 2017

27

1 reference

Europe PubMed Central

24 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1203625

0 references

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

A synthetic inhibitor of the mitogen-activated protein kinase cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Control of pRB phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Inhibition of cyclin-dependent kinases by purine analogues.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

21 January 2018

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203625

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1203625

1 reference

Europe PubMed Central

24 September 2017

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1 reference

Europe PubMed Central

24 September 2017

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