(Q40899249)

English

NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line (English)

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

0 references

0 references

cancer cell line

1 reference

based on heuristic

inferred from title

2

object named as

A V Patterson

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

5

object named as

I J Stratford

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

author name string

M P Saunders

1

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

E C Chinje

3

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

A L Harris

4

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

language of work or name

0 references

publication date

1 February 2000

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

British Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

82

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

3

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

651-656

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

https://scigraph.springernature.com/pub.10.1054/bjoc.1999.0977

0 references

Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

24 September 2017

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

24 September 2017

The experimental development of bioreductive drugs and their role in cancer therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

24 September 2017

Intermittent blood flow in a murine tumor: radiobiological effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

24 September 2017

Determinants of tumor blood flow: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

24 September 2017

Bioreductive drugs for cancer therapy: the search for tumor specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

25 September 2017

Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

25 September 2017

Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

25 September 2017

Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

17 June 2018

Tirapazamine is metabolized to its DNA-damaging radical by intranuclear enzymes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

19 August 2018

Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

19 August 2018

The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

19 August 2018

Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363339

19 August 2018

Enzymology of tirapazamine metabolism: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/10682679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/10682679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsomal reduction of 3-amino-1,2,4-benzotriazine 1,4-dioxide to a free radical

1 reference

https://pubmed.ncbi.nlm.nih.gov/10682679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10682679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10682679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10682679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10682679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1054/BJOC.1999.0977

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

ResearchGate publication ID

0 references

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