(Q40900972)

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An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

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scholarly article

1 reference

Europe PubMed Central

24 September 2017

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding (English)

1 reference

Europe PubMed Central

24 September 2017

X-ray crystallography

0 references

1 reference

based on heuristic

inferred from title

8

1 reference

Europe PubMed Central

24 September 2017

3

0 references

11

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author name string

Mun Peak Nyon

1

1 reference

Europe PubMed Central

24 September 2017

Tanya Prentice

2

1 reference

Europe PubMed Central

24 September 2017

John Kirkpatrick

4

1 reference

Europe PubMed Central

24 September 2017

Ganesh N Sivalingam

5

1 reference

Europe PubMed Central

24 September 2017

Geraldine Levy

6

1 reference

Europe PubMed Central

24 September 2017

Imran Haq

7

1 reference

Europe PubMed Central

24 September 2017

David A Lomas

9

1 reference

Europe PubMed Central

24 September 2017

John Christodoulou

10

1 reference

Europe PubMed Central

24 September 2017

Konstantinos Thalassinos

12

1 reference

Europe PubMed Central

24 September 2017

publication date

14 July 2015

1 reference

Europe PubMed Central

24 September 2017

Protein Science

1 reference

Europe PubMed Central

24 September 2017

24

1 reference

Europe PubMed Central

24 September 2017

8

1 reference

Europe PubMed Central

24 September 2017

1301-1312

1 reference

Europe PubMed Central

24 September 2017

Amphitrite: A program for processing travelling wave ion mobility mass spectrometry data

1 reference

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Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

1 reference

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The Z mutation alters the global structural dynamics of α1-antitrypsin

1 reference

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Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency

1 reference

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Evidence for two new solution states of ubiquitin by IMS-MS analysis

1 reference

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Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization

1 reference

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α-1-Antitrypsin deficiency: clinical variability, assessment, and treatment

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The molecular and cellular pathology of α₁-antitrypsin deficiency.

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Conformational States of macromolecular assemblies explored by integrative structure calculation.

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Activation state-selective kinase inhibitor assay based on ion mobility-mass spectrometry

1 reference

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The electrophoretic α1-globulin pattern of serum in α1-antitrypsin deficiency. 1963.

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24 September 2017

Ion mobility-mass spectrometry for structural proteomics

1 reference

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Therapeutic target-site variability in α1-antitrypsin characterized at high resolution

1 reference

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Targeting serpins in high-throughput and structure-based drug design

1 reference

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Mass spectrometry: come of age for structural and dynamical biology.

1 reference

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Understanding the complex mechanisms of β2-microglobulin amyloid assembly

1 reference

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Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

1 reference

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Conformational Conversion during Amyloid Formation at Atomic Resolution

1 reference

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Defining the mechanism of polymerization in the serpinopathies

1 reference

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Biomolecule analysis by ion mobility spectrometry

1 reference

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Mechanisms of emphysema in alpha1-antitrypsin deficiency: molecular and cellular insights

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24 September 2017

Phasercrystallographic software

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24 September 2017

Conformational pathology of the serpins: themes, variations, and therapeutic strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

24 September 2017

Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

24 September 2017

Small-molecule peptides inhibit Z alpha1-antitrypsin polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

24 September 2017

Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

24 September 2017

Molecular gymnastics: serpin structure, folding and misfolding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

24 September 2017

Scaling and assessment of data quality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

24 September 2017

Alpha-1-antitrypsin PI phenotypes S and Z in Europe: an analysis of the published surveys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

24 September 2017

Structure of a serpin-protease complex shows inhibition by deformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

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Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin

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From Levinthal to pathways to funnels

1 reference

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

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Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

24 September 2017

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

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Autophosphorylation activity of a soluble hexameric histidine kinase correlates with the shift in protein conformational equilibrium

1 reference

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17 June 2018

Structural dynamics associated with intermediate formation in an archetypal conformational disease.

1 reference

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1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin

1 reference

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Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

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Structural analysis of prion proteins by means of drift cell and traveling wave ion mobility mass spectrometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534181

19 August 2018

Kinetic instability of the serpin Z alpha1-antitrypsin promotes aggregation.

1 reference

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19 August 2018

Characterization of phosphorylated peptides using traveling wave-based and drift cell ion mobility mass spectrometry

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How small peptides block and reverse serpin polymerisation.

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https://pubmed.ncbi.nlm.nih.gov/26011795

12 December 2020

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Mechanisms of antithrombin polymerisation and heparin activation probed by the insertion of synthetic reactive loop peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/26011795

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Flexibility analysis of enzyme active sites by crystallographic temperature factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26011795

12 December 2020

based on heuristic

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Identifiers

10.1002/PRO.2706

1 reference

Europe PubMed Central

24 September 2017

1 reference

Europe PubMed Central

24 September 2017

1 reference

Europe PubMed Central

24 September 2017

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