(Q27653866)

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Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

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scholarly article

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Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design (English)

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object named as

Irene Nobeli

3

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object named as

Elena Miranda

2

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object named as

Bibek Gooptu

1

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Charlotte Summers

object named as

Charlotte Summers

7

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author name string

Meera Mallya

4

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Andrew Purkiss

5

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Sarah C Leigh Brown

6

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Russell L Phillips

8

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David A Lomas

9

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Tracey E Barrett

10

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publication date

10 April 2009

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Journal of Molecular Biology

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387

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4

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857-68

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Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

1 reference

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20 March 2017

Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates

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X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

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20 March 2017

Serpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerol

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20 March 2017

Interactions causing the kinetic trap in serpin protein folding

1 reference

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20 March 2017

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

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20 March 2017

Structure of a serpin-protease complex shows inhibition by deformation

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20 March 2017

Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease

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20 March 2017

Cleaved antitrypsin polymers at atomic resolution

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20 March 2017

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

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20 March 2017

A 2.6 A structure of a serpin polymer and implications for conformational disease

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20 March 2017

The anticoagulant activation of antithrombin by heparin

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20 March 2017

Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

UCSF Chimera--a visualization system for exploratory research and analysis

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20 March 2017

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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20 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

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20 March 2017

On the size of the active site in proteases. I. Papain

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Fragment-based lead discovery: leads by design

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20 March 2017

Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum

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20 March 2017

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

1 reference

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7 April 2017

SURFNET: a program for visualizing molecular surfaces, cavities, and intermolecular interactions

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7 April 2017

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.

1 reference

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29 September 2017

Novel procedure for modeling ligand/receptor induced fit effects.

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29 September 2017

Heteropolymerization of S, I, and Z alpha1-antitrypsin and liver cirrhosis.

1 reference

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29 September 2017

Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723994

29 September 2017

A hinge region mutation in C1-inhibitor (Ala436-->Thr) results in nonsubstrate-like behavior and in polymerization of the molecule.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723994

29 September 2017

What do dysfunctional serpins tell us about molecular mobility and disease?

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29 September 2017

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

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29 September 2017

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

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29 September 2017

The mechanism of alpha 1-antitrypsin polymerization probed by fluorescence spectroscopy

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2 June 2018

COOH-terminal substitutions in the serpin C1 inhibitor that cause loop overinsertion and subsequent multimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723994

2 June 2018

The Conformational Dynamics of a Metastable Serpin Studied by Hydrogen Exchange and Mass Spectrometry

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27 November 2018

How small peptides block and reverse serpin polymerisation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723994

27 November 2018

Different conformational changes within the F-helix occur during serpin folding, polymerization, and proteinase inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723994

27 November 2018

Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723994

27 November 2018

Probing the role of the F-helix in serpin stability through a single tryptophan substitution

1 reference

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27 November 2018

6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis

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27 November 2018

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

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27 November 2018

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

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27 November 2018

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmi

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human leukocyte granule elastase: rapid isolation and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of antithrombin polymerisation and heparin activation probed by the insertion of synthetic reactive loop peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JMB.2009.01.069

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Consolidated OpenCitations Corpus – April 2017

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PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

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