(Q33842205)

29 July 2017

title

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization (English)

1 reference

29 July 2017

James A Irving

1

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author name string

Imran Haq

2

1 reference

29 July 2017

Jennifer A Dickens

3

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29 July 2017

Sarah V Faull

4

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29 July 2017

David A Lomas

5

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29 July 2017

language of work or name

English

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publication date

1 May 2014

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29 July 2017

number of pages

13

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inferred from page(s)

published in

Biochemical Journal

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29 July 2017

volume

460

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29 July 2017

issue

1

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29 July 2017

page(s)

103-115

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Creative Commons Attribution 3.0 Unported

29 July 2017

copyright license

start time

25 July 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Acid Denaturation of alpha1-antitrypsin: characterization of a novel mechanism of serpin polymerization.

5 July 2018

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In vitro and in silico design of alpha1-antitrypsin mutants with different conformational stabilities

21 January 2018

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Probing the local conformational change of alpha1-antitrypsin

21 January 2018

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Osmolytes as modulators of conformational changes in serpins

21 January 2018

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The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20131650

Dimers initiate and propagate serine protease inhibitor polymerisation.

21 January 2018

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Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20131650

Different conformational changes within the F-helix occur during serpin folding, polymerization, and proteinase inhibition

21 January 2018

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A practical guide on how osmolytes modulate macromolecular properties.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20131650

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080824

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

29 October 2018

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https://api.crossref.org/works/10.1042%2FBJ20131650

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20131650

Kinetic Instability of p53 Core Domain Mutants

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20131650

The native metastable fold of C1-inhibitor is stabilized by disulfide bonds

21 January 2018

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12 December 2020

Prevention of polymerization of M and Z alpha1-Antitrypsin (alpha1-AT) with trimethylamine N-oxide. Implications for the treatment of alpha1-at deficiency

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12 December 2020

Aggregation of plasma Z type alpha 1-antitrypsin suggests basic defect for the deficiency

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12 December 2020

Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis

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12 December 2020

Effects of glycosylation on the folding and stability of human, recombinant and cleaved alpha 1-antitrypsin

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12 December 2020

Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

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12 December 2020

Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization

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12 December 2020

Metastability in the inhibitory mechanism of human alpha1-antitrypsin

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12 December 2020

Identifiers

DOI

10.1042/BJ20131650

1 reference

29 July 2017

1 reference

29 July 2017

1 reference