(Q44235328)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12460583%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Acid Denaturation of alpha1-antitrypsin: characterization of a novel mechanism of serpin polymerization (English)

1 reference

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15 December 2019

2

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15 December 2019

4

Stephen P Bottomley

1 reference

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15 December 2019

author name string

Glyn L Devlin

series ordinal

1

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15 December 2019

Geoffrey J Howlett

series ordinal

3

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15 December 2019

language of work or name

English

0 references

publication date

1 December 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12460583%20AND%20SRC:MED&resulttype=core&format=json

Journal of Molecular Biology

15 December 2019

published in

1 reference

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15 December 2019

volume

324

1 reference

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15 December 2019

issue

4

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15 December 2019

page(s)

859-870

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15 December 2019

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A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

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The mechanism of Z alpha 1-antitrypsin accumulation in the liver

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alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.

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Risk of cirrhosis and primary liver cancer in alpha 1-antitrypsin deficiency

7 January 2021

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Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation.

7 January 2021

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Structure of a serpin-protease complex shows inhibition by deformation

7 January 2021

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Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

7 January 2021

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Intrinsic fluorescence changes and rapid kinetics of proteinase deformation during serpin inhibition

7 January 2021

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Distortion of the active site of chymotrypsin complexed with a serpin

7 January 2021

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Trypsin complexed with alpha 1-proteinase inhibitor has an increased structural flexibility

7 January 2021

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What do dysfunctional serpins tell us about molecular mobility and disease?

7 January 2021

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Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

7 January 2021

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The molecular basis of alpha 1-antichymotrypsin deficiency in a heterozygote with liver and lung disease

7 January 2021

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COOH-terminal substitutions in the serpin C1 inhibitor that cause loop overinsertion and subsequent multimerization

7 January 2021

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Crucial residues in the carboxy-terminal end of C1 inhibitor revealed by pathogenic mutants impaired in secretion or function

7 January 2021

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Familial dementia caused by polymerization of mutant neuroserpin

7 January 2021

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Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

7 January 2021

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Biological implications of a 3 A structure of dimeric antithrombin

7 January 2021

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Polymerization of plasminogen activator inhibitor-1.

7 January 2021

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7 January 2021

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Conformational changes in intact and papain-modified alpha 1-proteinase inhibitor induced by guanidinium chloride

7 January 2021

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Effects of glycosylation on the folding and stability of human, recombinant and cleaved alpha 1-antitrypsin

7 January 2021

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7 January 2021

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Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis

7 January 2021

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The Z type variation of human alpha 1-antitrypsin causes a protein folding defect

7 January 2021

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7 January 2021

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Probing the equilibrium denaturation of the serpin alpha(1)-antitrypsin with single tryptophan mutants; evidence for structure in the urea unfolded state

7 January 2021

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Probing the role of the F-helix in serpin stability through a single tryptophan substitution

7 January 2021

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α1-Antitrypsin Polymerisation Can Occur by both Loop A and C Sheet Mechanisms

7 January 2021

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Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro

7 January 2021

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7 January 2021

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Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins

7 January 2021

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7 January 2021

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Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

7 January 2021

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A 2.6 A structure of a serpin polymer and implications for conformational disease

7 January 2021

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7 January 2021

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Preparation and characterization of latent alpha 1-antitrypsin

7 January 2021

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

7 January 2021

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7 January 2021

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7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12460583%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference