(Q41126460)

English

Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis

scientific article published on 25 June 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis (English)

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Pauline Douglas

1

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Ruiqiong Ye

2

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Laura Trinkle-Mulcahy

3

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Jessica A Neal

4

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Veerle De Wever

5

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Nick A Morrice

6

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Katheryn Meek

7

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Susan P Lees-Miller

8

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

publication date

25 June 2014

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Bioscience Reports

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

34

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

3

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

copyright license

Creative Commons Attribution 3.0 Unported

25 July 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

DNA-PKcs activates the Chk2-Brca1 pathway during mitosis to ensure chromosomal stability

1 reference

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Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response

1 reference

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27 September 2017

Identification of potential Plk1 targets in a cell-cycle specific proteome through structural dynamics of kinase and Polo box-mediated interactions

1 reference

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End-joining, translocations and cancer

1 reference

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Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A.

1 reference

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Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining

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Role of non-homologous end joining in V(D)J recombination

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N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.

1 reference

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27 September 2017

Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells

1 reference

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Choosing the right path: does DNA-PK help make the decision?

1 reference

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27 September 2017

Involvement of DNA-dependent protein kinase in normal cell cycle progression through mitosis

1 reference

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Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation

1 reference

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27 September 2017

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2

1 reference

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27 September 2017

Assembly and function of DNA double-strand break repair foci in mammalian cells

1 reference

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The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

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27 September 2017

A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation

1 reference

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27 September 2017

The Plk1-dependent phosphoproteome of the early mitotic spindle

1 reference

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The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4069685

27 September 2017

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4069685

27 September 2017

Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.

1 reference

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27 September 2017

Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.

1 reference

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Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

1 reference

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DNA-PK: the means to justify the ends?

1 reference

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'... The end of the beginning': cdk1 thresholds and exit from mitosis

1 reference

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27 September 2017

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

1 reference

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Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse

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The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain

1 reference

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ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress

1 reference

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Phosphoproteome analysis of the human mitotic spindle

1 reference

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Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

1 reference

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Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

1 reference

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Proteome analysis of the human mitotic spindle

1 reference

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1 reference

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Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

1 reference

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Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.

1 reference

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Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

1 reference

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Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

1 reference

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Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination

1 reference

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Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

1 reference

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

1 reference

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1 reference

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Purification of mitotic spindles from cultured human cells

1 reference

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DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4069685

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γH2AX foci formation in the absence of DNA damage: mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway

1 reference

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Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage.

1 reference

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Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks

1 reference

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Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

1 reference

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DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24844881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24844881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the tumour-suppressor genes CHK2 and BRCA1 results in chromosomal instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/24844881

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BSR20140051

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

ResearchGate publication ID

0 references

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