(Q28266265)

1

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Vidyasagar Malshetty

2

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Dailia Francis

3

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Patricia Cortes

Somatic generation of antibody diversity

4

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language of work or name

English

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publication date

December 2012

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published in

Immunologic Research

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volume

54

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issue

1-3

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page(s)

233-46

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cites work

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Unraveling V(D)J recombination; insights into gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The mechanism and regulation of chromosomal V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA hairpin opening mediated by the RAG1 and RAG2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Role and regulation of human XRCC4-like factor/cernunnos

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

VDJ recombination: Artemis and its in vivo role in hairpin opening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Polymerases in nonhomologous end joining: building a bridge over broken chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

21 January 2018

12 December 2020

Naturally occurring primary deficiencies of the immune system

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Severe combined immunodeficiency. A model disease for molecular immunology and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Primary immunodeficiency diseases: an experimental model for molecular medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A severe form of human combined immunodeficiency due to mutations in DNA ligase IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Defective Artemis nuclease is characterized by coding joints with microhomology in long palindromic-nucleotide stretches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

21 January 2018

Reviewing Omenn syndrome

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Partial V(D)J recombination activity leads to Omenn syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Omenn syndrome due to ARTEMIS mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Omenn syndrome does not live by V(D)J recombination alone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Regulation of DNA double-strand break repair pathway choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Genome maintenance mechanisms for preventing cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The DNA damage response: ten years after

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Sensing and repairing DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Repair of DNA double strand breaks by non-homologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The mechanism of non-homologous end-joining: a synopsis of synapsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Synapsis of DNA ends by DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA polymerases in adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The mechanism of human nonhomologous DNA end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A biochemically defined system for mammalian nonhomologous DNA end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Ku recruits XLF to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Molecular mechanism of protein assembly on DNA double-strand breaks in the non-homologous end-joining pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Mechanisms that promote and suppress chromosomal translocations in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Origin of chromosomal translocations in lymphoid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A severe combined immunodeficiency mutation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Impairment of V(D)J recombination in double-strand break repair mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Nonhomologous end joining and V(D)J recombination require an additional factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Evidence for Ku70/Ku80 association with full-length RAG1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A recombinase diversified: new functions of the RAG proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The roles of the RAG1 and RAG2 "non-core" regions in V(D)J recombination and lymphocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The RAG2 C terminus suppresses genomic instability and lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Autoubiquitylation of the V(D)J recombinase protein RAG1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A means to a DNA end: the many roles of Ku.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The ACF1 complex is required for DNA double-strand break repair in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Association of terminal deoxynucleotidyl transferase with Ku

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Ku recruits the XRCC4-ligase IV complex to DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Defining interactions between DNA-PK and ligase IV/XRCC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA-PK: the means to justify the ends?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

XRCC4's interaction with XLF is required for coding (but not signal) end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA-PK autophosphorylation facilitates Artemis endonuclease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Radiation-induced delayed cell death in a hypomorphic Artemis cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Phosphorylation of Artemis following irradiation-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Eukaryotic DNA ligases: structural and functional insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

BRCT domains: easy as one, two, three

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

The BRCT Domain Is a Phospho-Protein Binding Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Requirement for DNA ligase IV during embryonic neuronal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Impact of DNA ligase IV on the fidelity of end joining in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Crystal structure of human XLF: a twist in nonhomologous DNA end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

XLF regulates filament architecture of the XRCC4·ligase IV complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Familial Reticuloendotheliosis with Eosinophilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Hematopoietic stem cell transplantation in Omenn syndrome: a single-center experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

Rag mutations reveal robust alternative end joining

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS12026-012-8329-Z

21 January 2018

12 December 2020

Artemis, a novel guardian of the genome

1 reference

12 December 2020

The most frequent DCLRE1C (ARTEMIS) mutations are based on homologous recombination events

1 reference

12 December 2020

Damaging-agent sensitivity of Artemis-deficient cell lines

1 reference

12 December 2020

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1 reference

12 December 2020

Two SCID cases with Cernunnos-XLF deficiency successfully treated by hematopoietic stem cell transplantation.

1 reference

12 December 2020

VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity

1 reference

12 December 2020

Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK.

1 reference

12 December 2020

Double-strand-break-induced homologous recombination in mammalian cells

1 reference

12 December 2020

A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype.

1 reference

12 December 2020

A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining.

1 reference

12 December 2020

Interactive competition between homologous recombination and non-homologous end joining

1 reference

12 December 2020

V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation

1 reference

12 December 2020

The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination

1 reference

12 December 2020

Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants

1 reference

12 December 2020

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

12 December 2020

Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome

1 reference

12 December 2020