(Q34292616)

1 August 2017

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title

Unraveling V(D)J recombination; insights into gene regulation (English)

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1 August 2017

David Jung

1

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1 August 2017

Frederick W Alt

series ordinal

2

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1 August 2017

language of work or name

English

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publication date

1 January 2004

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1 August 2017

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1 August 2017

volume

116

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1 August 2017

issue

2

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1 August 2017

page(s)

299-311

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Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

1 August 2017

cites work

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7 January 2021

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

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7 January 2021

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions

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7 January 2021

Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain

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7 January 2021

Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice

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7 January 2021

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

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7 January 2021

The mechanism and regulation of chromosomal V(D)J recombination

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7 January 2021

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

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7 January 2021

Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line

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7 January 2021

A complete immunoglobulin gene is created by somatic recombination

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7 January 2021

Contribution of Receptor Editing to the Antibody Repertoire

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7 January 2021

OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes

1 reference

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7 January 2021

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

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7 January 2021

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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7 January 2021

Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements

1 reference

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7 January 2021

The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

1 reference

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7 January 2021

V(D)J recombination and RAG-mediated transposition in yeast.

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7 January 2021

Nonhomologous end joining and V(D)J recombination require an additional factor

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7 January 2021

T-cell antigen receptor genes and T-cell recognition

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7 January 2021

Synapsis of DNA ends by DNA-dependent protein kinase

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7 January 2021

The molecular basis of antibody formation: a paradox

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7 January 2021

Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.

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7 January 2021

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.

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7 January 2021

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

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7 January 2021

The C-terminal portion of RAG2 protects against transposition in vitro

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https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The basis for the mechanistic bias for deletional over inversional V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

V(D)J recombination: RAG proteins, repair factors, and regulation

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7 January 2021

Mice lacking TdT: mature animals with an immature lymphocyte repertoire

1 reference

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7 January 2021

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Factors and forces controlling V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Sensing and repairing DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Ordered assembly of the V(D)J synaptic complex ensures accurate recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

1 reference

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7 January 2021

DNA double-strand breaks: signaling, repair and the cancer connection

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7 January 2021

Allelic exclusion at the TCRbeta locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes

1 reference

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7 January 2021

Gene segment selection in V(D)J recombination: accessibility and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

1 reference

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7 January 2021

Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Joining of VK to JK gene segments in a retroviral vector introduced into lymphoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The mechanism of V(D)J recombination: site-specificity, reaction fidelity and immunologic diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The pre-B cell receptor and its role in proliferation and Ig heavy chain allelic exclusion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

A role for histone acetylation in the developmental regulation of VDJ recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The role of DNA breaks in genomic instability and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Sequence analysis of immunoglobulin light chain messenger RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

RAG2 is regulated differentially in B and T cells by elements 5' of the promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Kappa chain monoallelic demethylation and the establishment of allelic exclusion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Asynchronous replication and allelic exclusion in the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Assembly of the RAG1/RAG2 synaptic complex

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Regulation of RAG expression in developing lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Receptor selection in B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

DNA-Rag Protein Interactions in the Control of Selective D Gene Utilization in the TCRβ Locus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues

1 reference

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7 January 2021

Clonal selection and learning in the antibody system

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Histone H2A variants H2AX and H2AZ

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Restraining the V(D)J recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The V(D)J recombination activating gene, RAG-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangements in heavy chain V-region gene segments

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?

1 reference

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7 January 2021

1 reference

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7 January 2021

A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Full-length RAG-2, and Not Full-length RAG-1, Specifically Suppresses RAG-mediated Transposition but Not Hybrid Joint Formation or Disintegration

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

New insights into V(D)J recombination and its role in the evolution of the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Somatic generation of antibody diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversity

1 reference

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7 January 2021

Initiation of V(D)J recombination in a cell-free system.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Rearrangement of genetic information may produce immunoglobulin diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

The RAG1 N-terminal domain is an E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900039-X

7 January 2021

10.1016/S0092-8674(04)00039-X

Identifiers

DOI

1 reference

1 August 2017

1 reference