(Q35219034)

7 August 2017

1 reference

title

Restraining the V(D)J recombinase (English)

1 reference

7 August 2017

David B Roth

1

1 reference

PubMed ID

12974480

7 August 2017

language of work or name

1 reference

1 August 2003

1 reference

Nature Reviews Immunology

7 August 2017

1 reference

7 August 2017

3

1 reference

7 August 2017

656-666

1 reference

7 August 2017

8

1 reference

https://scigraph.springernature.com/pub.10.1038/nri1152

7 August 2017

0 references

cites work

Lymphoid malignancies: the dark side of B-cell differentiation

1 reference

Unequal access: regulating V(D)J recombination through chromatin remodeling

31 March 2020

1 reference

The mechanism and regulation of chromosomal V(D)J recombination

31 March 2020

1 reference

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

31 March 2020

1 reference

V(D)J recombination: a functional definition of the joining signals

31 March 2020

1 reference

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

31 March 2020

1 reference

Stimulation of V(D)J cleavage by high mobility group proteins

31 March 2020

1 reference

Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination

31 March 2020

1 reference

Definition of a core region of RAG-2 that is functional in V(D)J recombination

31 March 2020

1 reference

Expression and V(D)J recombination activity of mutated RAG-1 proteins

31 March 2020

1 reference

Analysis of regions of RAG-2 important for V(D)J recombination

31 March 2020

1 reference

Regions of RAG1 protein critical for V(D)J recombination

31 March 2020

1 reference

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

31 March 2020

1 reference

Characterization of broken DNA molecules associated with V(D)J recombination

31 March 2020

1 reference

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

31 March 2020

1 reference

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

31 March 2020

1 reference

The RAG proteins in V(D)J recombination: more than just a nuclease

31 March 2020

1 reference

V(D)J recombination: RAG proteins, repair factors, and regulation

31 March 2020

1 reference

31 March 2020

1 reference

VDJ recombination: a transposase goes to work

31 March 2020

1 reference

Tn10 transposition via a DNA hairpin intermediate

31 March 2020

1 reference

Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

31 March 2020

1 reference

Transposition of maize Ac/Ds transposable elements in the yeast Saccharomyces cerevisiae

31 March 2020

1 reference

Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage

31 March 2020

1 reference

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

31 March 2020

1 reference

The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire

31 March 2020

1 reference

The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo

31 March 2020

1 reference

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

31 March 2020

1 reference

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

31 March 2020

1 reference

Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors.

31 March 2020

1 reference

Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.

31 March 2020

1 reference

Novel strand exchanges in V(D)J recombination

31 March 2020

1 reference

Unusual immunoglobulin gene rearrangement leads to replacement of recombinational signal sequences.

31 March 2020

1 reference

V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation

31 March 2020

1 reference

Inversions produced during V(D)J rearrangement at IgH, the immunoglobulin heavy-chain locus

31 March 2020

1 reference

How to make ends meet in V(D)J recombination

31 March 2020

1 reference

Nonhomologous end joining and V(D)J recombination require an additional factor

31 March 2020

1 reference

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

31 March 2020

1 reference

Association of terminal deoxynucleotidyl transferase with Ku

31 March 2020

1 reference

Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase

31 March 2020

1 reference

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

31 March 2020

1 reference

The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase

31 March 2020

1 reference

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

31 March 2020

1 reference

Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

31 March 2020

1 reference

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

31 March 2020

1 reference

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

31 March 2020

1 reference

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

31 March 2020

1 reference

Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

31 March 2020

1 reference

Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro

31 March 2020

1 reference

Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

31 March 2020

1 reference

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

31 March 2020

1 reference

Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

31 March 2020

1 reference

DNA hairpin opening mediated by the RAG1 and RAG2 proteins

31 March 2020

1 reference

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

31 March 2020

1 reference

VDJ recombination: Artemis and its in vivo role in hairpin opening

31 March 2020

1 reference

The RAG1 N-terminal domain is an E3 ubiquitin ligase

31 March 2020

1 reference

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

31 March 2020

1 reference

Mechanisms of chromosomal translocations in B cell lymphomas

31 March 2020

1 reference

Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes

31 March 2020

1 reference

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells

31 March 2020

1 reference

T cell receptor gene trans-rearrangements: chimeric gamma-delta genes in normal lymphoid tissues

31 March 2020

1 reference

Assessing the pathogenic potential of the V(D)J recombinase by interlocus immunoglobulin light-chain gene rearrangement

31 March 2020

1 reference

Hybrid T cell receptor genes formed by interlocus recombination in normal and ataxia-telangiectasis lymphocytes

31 March 2020

1 reference

Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks

31 March 2020

1 reference

Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners

31 March 2020

1 reference

Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products

31 March 2020

1 reference

V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells

31 March 2020

1 reference

Rejoining of DNA by the RAG1 and RAG2 proteins.

31 March 2020

1 reference

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

31 March 2020

1 reference

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations.

31 March 2020

1 reference

New insights into V(D)J recombination and its role in the evolution of the immune system

31 March 2020

1 reference

In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

31 March 2020

1 reference

Targeted transposition by the V(D)J recombinase

31 March 2020

1 reference

Restrictions limiting the generation of DNA double strand breaks during chromosomal V(D)J recombination

31 March 2020

1 reference

Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

31 March 2020

1 reference

Atm-deficient mice: a paradigm of ataxia telangiectasia

31 March 2020

1 reference

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

31 March 2020

1 reference

Sensing of intermediates in V(D)J recombination by ATM.

31 March 2020

1 reference

Intermolecular V(D)J recombination is prohibited specifically at the joining step

31 March 2020

1 reference

Intermolecular V(D)J recombination

31 March 2020

1 reference

Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining

31 March 2020

1 reference

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

31 March 2020

1 reference

The importance of repairing stalled replication forks

31 March 2020

1 reference

DNA double strand break repair and chromosomal translocation: lessons from animal models

31 March 2020

1 reference

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

31 March 2020

1 reference

Sensing and repairing DNA double-strand breaks

31 March 2020

1 reference

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

31 March 2020

1 reference

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

31 March 2020

1 reference

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

31 March 2020

1 reference

Ku70: a candidate tumor suppressor gene for murine T cell lymphoma

31 March 2020

1 reference

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

31 March 2020

1 reference

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

31 March 2020

1 reference

Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis

31 March 2020

1 reference

The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.

31 March 2020

1 reference

Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions

31 March 2020

1 reference

Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors

31 March 2020

1 reference

Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents

31 March 2020

1 reference

Somatic Cells Efficiently Join Unrelated DNA Segments End-to-End

31 March 2020

1 reference

Mechanisms of nonhomologous recombination in mammalian cells

31 March 2020

1 reference

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction

31 March 2020

1 reference

Double-strand break repair in Ku86- and XRCC4-deficient cells

31 March 2020

1 reference

DNA end-joining catalyzed by human cell-free extracts

31 March 2020

1 reference

Amplifying mechanisms of lymphomagenesis

31 March 2020

1 reference

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

31 March 2020

1 reference

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

31 March 2020

1 reference

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

31 March 2020

1 reference

Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.

31 March 2020

1 reference

Cell-free V(D)J recombination

31 March 2020

1 reference

A recombinase diversified: new functions of the RAG proteins

31 March 2020

1 reference

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

31 March 2020

1 reference

The V(D)J recombinase efficiently cleaves and transposes signal joints

31 March 2020

1 reference

Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination

31 March 2020

1 reference

Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.

31 March 2020

1 reference

RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences

31 March 2020

1 reference

Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

31 March 2020

1 reference

The C-terminal portion of RAG2 protects against transposition in vitro

31 March 2020

1 reference

Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

31 March 2020

1 reference

T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

31 March 2020

1 reference

Single active site catalysis of the successive phosphoryl transfer steps by DNA transposases: insights from phosphorothioate stereoselectivity

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1152

1 reference

PubMed ID

12974480

Dimensions Publication ID

7 August 2017

0 references

1 reference

PubMed ID

12974480