(Q41129970)

English

Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis

scientific article published on 11 October 2010

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scholarly article

1 reference

Europe PubMed Central

27 September 2017

Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis (English)

1 reference

Europe PubMed Central

27 September 2017

Hans Robert Kalbitzer

7

object named as

Hans Robert Kalbitzer

1 reference

Europe PubMed Central

27 September 2017

author name string

Michael Spoerner

1

1 reference

Europe PubMed Central

27 September 2017

Constantin Hozsa

2

1 reference

Europe PubMed Central

27 September 2017

Johann A Poetzl

3

1 reference

Europe PubMed Central

27 September 2017

Kerstin Reiss

4

1 reference

Europe PubMed Central

27 September 2017

Petra Ganser

5

1 reference

Europe PubMed Central

27 September 2017

Matthias Geyer

6

1 reference

Europe PubMed Central

27 September 2017

language of work or name

0 references

publication date

11 October 2010

1 reference

Europe PubMed Central

27 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

27 September 2017

285

1 reference

Europe PubMed Central

27 September 2017

51

1 reference

Europe PubMed Central

27 September 2017

39768-39778

1 reference

Europe PubMed Central

27 September 2017

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Allosteric modulation of Ras positions Q61 for a direct role in catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Solution structure of the Ras binding domain of the protein kinase Byr2 from Schizosaccharomyces pombe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Dynamic properties of the Ras switch I region and its importance for binding to effectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Ras/Rap effector specificity determined by charge reversal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Multiple Ras functions can contribute to mammalian cell transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

27 September 2017

Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

17 June 2018

Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

17 June 2018

Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

17 June 2018

Fundamental link between folding states and functional states of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

19 August 2018

Kinetic determination of the GTPase activity of Ras proteins by means of a luminescent terbium complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

19 August 2018

Structure of the G60A mutant of Ras: implications for the dominant negative effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

19 August 2018

Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

19 August 2018

Solid-state 31P NMR spectroscopy of microcrystals of the Ras protein and its effector loop mutants: comparison between crystalline and solution state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

19 August 2018

Observation of slow dynamic exchange processes in Ras protein crystals by 31P solid state NMR spectroscopy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

19 August 2018

Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

19 August 2018

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000958

19 August 2018

Surface Change of Ras Enabling Effector Binding Monitored in Real Time at Atomic Resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145235

21 January 2018

Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20937837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

31P-NMR spectra of the Ha-ras p21.nucleotide complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20937837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPgammaS

1 reference

https://pubmed.ncbi.nlm.nih.gov/20937837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1 reference

https://pubmed.ncbi.nlm.nih.gov/20937837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indirect Referencing of 31P and 19F NMR Spectra

1 reference

https://pubmed.ncbi.nlm.nih.gov/20937837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and biochemical analysis of Ras-effector signaling via RalGDS

1 reference

https://pubmed.ncbi.nlm.nih.gov/20937837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel mechanism for the modulation of the Ras-effector interaction by small molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/20937837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.145235

1 reference

Europe PubMed Central

27 September 2017

release_a7lzmklqnzgoffdqv6jfuiykvy

1 reference

https://api.fatcat.wiki/v0/release/a7lzmklqnzgoffdqv6jfuiykvy

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

27 September 2017

1 reference

Europe PubMed Central

27 September 2017

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