(Q41149344)

27 September 2017

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title

Targeting hepatitis B therapy to the liver. Clinical pharmacokinetic considerations (English)

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27 September 2017

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P C Rensen

1

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27 September 2017

R L de Vrueh

series ordinal

2

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27 September 2017

T J van Berkel

series ordinal

3

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27 September 2017

publication date

1 August 1996

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Clinical Pharmacokinetics

27 September 2017

published in

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27 September 2017

volume

31

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27 September 2017

issue

2

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27 September 2017

page(s)

131-155

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https://scigraph.springernature.com/pub.10.2165/00003088-199631020-00005

27 September 2017

exact match

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cites work

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Effect of Alpha-Interferon Treatment in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B

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Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication

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In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate modified antisense oligodeoxynucleotides.

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A conjugate of lactosaminated poly-L-lysine with adenine arabinoside monophosphate, administered to mice by intramuscular route, accomplishes a selective delivery of the drug to the liver

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A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus-specific proteins in MDCK cells

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Stable expression and replication of hepatitis B virus genome in an integrated state in a human hepatoma cell line transfected with the cloned viral DNA

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Antiviral activity of 2',3'-dideoxy-beta-L-5-fluorocytidine (beta-L-FddC) and 2',3'-dideoxy-beta-L-cytidine (beta-L-ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro

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12 December 2020

Organ distribution of a conjugate of adenine arabinoside monophosphate with lactosaminated albumin in the rat

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12 December 2020

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12 December 2020

Antisense has growing pains

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12 December 2020

Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy

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12 December 2020

Galactosylated poly(L-lysine) as a hepatotropic carrier of 9-beta-D-arabinofuranosyladenine 5'-monophosphate

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12 December 2020

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Phosphorothioate oligonucleotides bind in a non sequence-specific manner to the nucleolar protein C23/nucleolin

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Lactic acidosis complicating the acquired immunodeficiency syndrome

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The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

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12 December 2020

Hepatitis B virus immunopathogenesis

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12 December 2020

Oligodeoxynucleotide stability in subcellular extracts and culture media

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12 December 2020

Interferon alfa for patients with clinically apparent cirrhosis due to chronic hepatitis B

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12 December 2020

Conjugation of adenine arabinoside 5'-monophosphate to arabinogalactan: synthesis, characterization, and antiviral activity

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12 December 2020

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

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12 December 2020

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

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12 December 2020

Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma. Asialoglycoprotein receptor in cirrhosis and liver cell carcinoma

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12 December 2020

Physical and chemical characteristics of apolipoprotein A-I-lipid complexes produced by Chinese hamster ovary cells transfected with the human apolipoprotein A-I gene

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12 December 2020

Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model

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12 December 2020

Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus

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12 December 2020

Synthesis of the dioleoyl derivative of iododeoxyuridine and its incorporation into reconstituted high density lipoprotein particles

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12 December 2020

The molecular biology of the hepatitis B viruses

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12 December 2020

Receptor mediated glycotargeting

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12 December 2020

The management of chronic hepatitis B.

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12 December 2020

Inhibition of woodchuck hepatitis virus replication by adenine arabinoside monophosphate coupled to lactosaminated poly-L-lysine and administered by intramuscular route

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12 December 2020

The streaming liver II. Hepatocyte life history

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12 December 2020

Which patients with chronic hepatitis B virus infection will respond to alpha-interferon therapy? A statistical analysis of predictive factors

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12 December 2020

Enhanced inhibition of virus DNA synthesis in hepatocytes by trifluorothymidine coupled to asialofetuin

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12 December 2020

The pathogenesis of vacuoles produced in rat and mouse liver cells by a conjugate of adenine arabinoside monophosphate with lactosaminated albumin

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12 December 2020

Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex

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12 December 2020

Thymosins: structure, function and therapeutic applications

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12 December 2020

Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates

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12 December 2020

Biochemical and biological effects of nonionic nucleic acid methylphosphonates

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12 December 2020

Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells

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12 December 2020

Abnormal surface distribution of the human asialoglycoprotein receptor in cirrhosis

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12 December 2020

Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver cells

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12 December 2020

A quantitative evaluation of apoptotic bodies in rat liver

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12 December 2020

Lactosylated high density lipoprotein: a potential carrier for the site-specific delivery of drugs to parenchymal liver cells

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12 December 2020

Oligodeoxynucleotides as inhibitors of gene expression: a review.

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12 December 2020

Liver function in acute viral hepatitis as determined by a hepatocyte-specific ligand: 99mTc-galactosyl-neoglycoalbumin

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12 December 2020

Prolonged infection with hepatitis B virus and association between low blood cholesterol concentration and liver cancer

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12 December 2020

The asialoglycoprotein receptor: relationships between structure, function, and expression

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12 December 2020

LDL-mediated drug targeting

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12 December 2020

Endonexin II, present on human liver plasma membranes, is a specific binding protein of small hepatitis B virus (HBV) envelope protein

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12 December 2020

Replication of animal mitochondrial DNA.

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12 December 2020

Therapy of chronic hepatitis B with a 6-month course of ribavirin.

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12 December 2020

Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution

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12 December 2020

Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus

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12 December 2020

Selective delivery to the liver of antiviral nucleoside analogs coupled to a high molecular mass lactosaminated poly-L-lysine and administered to mice by intramuscular route.

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12 December 2020

Selective inhibition of ectromelia virus DNA synthesis in hepatocytes by adenine-9-β-D-arabinofuranoside (ara-A) and adenine-9-β-D-arabinofuranoside 5′-monophosphate (ara-AMP) conjugated to asialofetuin

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12 December 2020

Controlled clinical trial of acyclovir in chronic hepatitis B virus infection

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12 December 2020

Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture

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12 December 2020

The role of interferon in the treatment of viral hepatitis

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12 December 2020

Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus

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12 December 2020

Modulation of oligonucleotide duplex and triplex stability via hydrophobic interactions

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12 December 2020

Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy

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12 December 2020

Coupling of antiviral nucleoside analogs to lactosaminated human albumin by using the imidazolides of their phosphoric esters

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12 December 2020

Therapy of chronic type B hepatitis with adenine arabinoside and adenine arabinoside monophosphate

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12 December 2020

Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication

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12 December 2020

Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo.

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12 December 2020

Clinical aspects of hepatitis B virus infection

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12 December 2020

The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse

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12 December 2020

Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides

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12 December 2020

The secretory core protein of human hepatitis B virus is expressed on the cell surface

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12 December 2020

Carbohydrate-Specific Receptors of the Liver

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12 December 2020

Conjugates of ara-AMP with lactosaminated albumin: a study on their immunogenicity in mouse and rat

1 reference

12 December 2020

Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases

1 reference

12 December 2020

Inhibition of hepatitis B virus replication by adenine arabinoside monophosphate coupled to lactosaminated albumin. Efficacy and minimal active dose.

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12 December 2020

Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion

1 reference

12 December 2020

Selective penetration and pharmacological activity of lactosaminated albumin conjugates of adenine arabinoside 5-monophosphate (ara-AMP) in mouse liver

1 reference

12 December 2020

Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates

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12 December 2020

Molecular mechanisms of action of ribavirin

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12 December 2020

Molecular events in the pathogenesis of hepadnavirus-associated hepatocellular carcinoma

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12 December 2020

Improved leishmanicidal effect of phosphorotioate antisense oligonucleotides by LDL-mediated delivery

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12 December 2020

Randomized controlled trial of adenine arabinoside monophosphate for chronic type B hepatitis

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12 December 2020

Development of lipoprotein-like lipid particles for drug targeting: neo-high density lipoproteins.

1 reference

12 December 2020

Inhibition of hepatitis B virus replication by vidarabine monophosphate conjugated with lactosaminated serum albumin.

1 reference

12 December 2020

Ultrastructural changes associated with reduced mitochondrial DNA and impaired mitochondrial function in the presence of 2'3'-dideoxycytidine

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12 December 2020

A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. The Hepatitis Interventional Therapy Group

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12 December 2020

Hepatocyte targeting of adenine-9-beta-D-arabinofuranoside 5' -monophosphate (ara-AMP) coupled to lactosaminated albumin

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12 December 2020

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12 December 2020

Distinct hepatic receptors for low density lipoprotein and apolipoprotein E in humans

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12 December 2020

Recognition of chylomicron remnants and β-migrating very-low-density lipoproteins by the remnant receptor of parenchymal liver cells is distinct from the liver α2-macroglobulin-recognition site

1 reference

12 December 2020

Efficacy of lamivudine on replication of hepatitis B virus in HIV-infected patients

1 reference

12 December 2020

Antisense phosphorothioate oligonucleotides: selective killing of the intracellular parasite Leishmania amazonensis.

1 reference

12 December 2020

Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).

1 reference

12 December 2020

Coupling of the antiviral drug ara-AMP to lactosaminated albumin leads to specific uptake in rat and human hepatocytes

1 reference

12 December 2020

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound

1 reference

12 December 2020

Lactosaminated human serum albumin as hepatotropic drug carrier. Rate of uptake by mouse liver

1 reference

12 December 2020

A pilot study of 2',3'-dideoxyinosine for the treatment of chronic hepatitis B

1 reference

12 December 2020

Pharmacokinetics, oral bioavailability, and metabolism in mice and cynomolgus monkeys of (2'R,5'S-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, an agent active against human immunodeficiency virus and human hepatitis B virus

1 reference

12 December 2020

Adenine arabinoside monophosphate and acyclovir monophosphate coupled to lactosaminated albumin reduce woodchuck hepatitis virus viremia at doses lower than do the unconjugated drugs

1 reference

12 December 2020

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

1 reference

12 December 2020

Thymosin treatment of chronic hepatitis B: a placebo-controlled pilot trial

1 reference

12 December 2020

Transferrin receptor mediates uptake and presentation of hepatitis B envelope antigen by T lymphocytes

1 reference

12 December 2020

Interaction between hepatitis B surface proteins and monomeric human serum albumin

1 reference

12 December 2020

Characterization of the antiviral effects of 2' carbodeoxyguanosine in ducks chronically infected with duck hepatitis B virus

1 reference

12 December 2020

Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates

1 reference

12 December 2020

Serum desialylated glycoproteins in patients with hepatobiliary dysfunction

1 reference

12 December 2020

Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates

1 reference

12 December 2020

Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells

1 reference

12 December 2020

Antisense oligodeoxyribonucleotides inhibit the expression of the gene for hepatitis B virus surface antigen

1 reference

12 December 2020

Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

1 reference

12 December 2020

Development of antiviral therapy for chronic infection with hepatitis B virus.

1 reference

12 December 2020

Synthesis and biological evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides as potential antiviral agents against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).

1 reference

12 December 2020

Conjugates between monoclonal antibodies to HBsAg and cytosine arabinoside

1 reference

12 December 2020

Acute pancreatitis as a common complication of 2',3'-dideoxyinosine therapy in the acquired immunodeficiency syndrome

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12 December 2020

Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus

1 reference

12 December 2020

Antisense oligonucleotides as antiviral agents

1 reference

12 December 2020

No effect of zidovudine on hepatitis B virus replication in homosexual men with symptomatic HIV-1 infection

1 reference

12 December 2020

Inhibition of hepatitis B virus by antisense oligodeoxynucleotides

1 reference

12 December 2020

Drug targeting in antiviral chemotherapy. A chemically stable conjugate of 9-beta-D-arabinofuranosyl-adenine 5'-monophosphate with lactosaminated albumin accomplishes a selective delivery of the drug to liver cells

1 reference

12 December 2020

Adenine arabinoside 5'-monophosphate in patients with chronic hepatitis B: comparison of the efficacy in patients with high and low viral replication.

1 reference

12 December 2020

Cellular metabolism of 2',3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro

1 reference

12 December 2020

Targeting of drugs to the liver

1 reference

12 December 2020

Prospectives on the treatment of chronic hepatitis B and chronic hepatitis C with thymic peptides and antiviral agents

1 reference

12 December 2020

Effective incorporation of 2'-O-methyl-oligoribonucleotides into liposomes and enhanced cell association through modification with thiocholesterol

1 reference

12 December 2020

Synthesis of alkylating oligonucleotide derivatives containing cholesterol or phenazinium residues at their 3'-terminus and their interaction with DNA within mammalian cells

1 reference

12 December 2020

Selective liver targeting of antivirals by recombinant chylomicrons--a new therapeutic approach to hepatitis B

1 reference

12 December 2020

Distribution of a conjugate of 9-beta-D-arabinofuranosyladenine 5'-monophosphate (ara-AMP) with lactosaminated albumin in parenchymal and sinusoidal cells of rat liver

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12 December 2020

Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

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12 December 2020

Fulminant hepatic failure associated with 2',3'-dideoxyinosine (ddI)

1 reference

12 December 2020

Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding.

1 reference

12 December 2020

Inhibition of duck hepatitis B virus DNA replication by antiviral chemotherapy with ganciclovir-nalidixic acid

1 reference

12 December 2020

Receptor-mediated transport of oligodeoxynucleotides into hepatic cells.

1 reference

12 December 2020

Clinical immunology and infectious diseases.

1 reference

12 December 2020

Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin

1 reference

12 December 2020

A randomized study of the effects of adenine arabinoside 5'-monophosphate (short or long courses) and lymphoblastoid interferon on hepatitis B virus replication.

1 reference

12 December 2020

Hepatitis B immunization strategies: expanding the target

1 reference

12 December 2020

Does antisense exist?

1 reference

12 December 2020

Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidine

1 reference

12 December 2020

Facile preparation of nuclease resistant 3' modified oligodeoxynucleotides

1 reference

12 December 2020

The asialoglycoprotein receptor mediates hepatic binding and uptake of natural hepatitis B virus particles derived from viraemic carriers

1 reference

12 December 2020

Studies on the inhibition of mitochondrial DNA replication by 3'-azido-3'-deoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication

1 reference

12 December 2020

Biochemical and genetic evidence for the hepatitis B virus replication strategy

1 reference

12 December 2020

Adenine arabinoside monophosphate coupled to lactosaminated human albumin administered for 4 weeks in patients with chronic type B hepatitis decreased viremia without producing significant side effects

1 reference

12 December 2020

Hepatitis B virus infection in cultured human lymphoblastoid cells

1 reference

12 December 2020

Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration

1 reference

12 December 2020

Hepadnavirus infection requires interaction between the viral pre-S domain and a specific hepatocellular receptor.

1 reference

12 December 2020

Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells

1 reference

12 December 2020

The hepatitis B virus

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12 December 2020

Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues

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12 December 2020

Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan

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12 December 2020

Pharmacokinetics of antisense oligonucleotides

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12 December 2020

Mitochondrial toxicity of antiviral drugs

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12 December 2020

Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma

1 reference

12 December 2020

Circulating p24 antigen levels and responses to dideoxycytidine in human immunodeficiency virus (HIV) infections. A phase I and II study

1 reference

12 December 2020

Antiviral agents in hepatitis B virus transfected cell lines: inhibitory and cytotoxic effect related to time of treatment

1 reference

12 December 2020

Synthesis and physical properties ofanti-HIV antisense oligonucleotides bearing terminal lipophilic groups

1 reference

12 December 2020

Biochemical pharmacology of (+)- and (-)-2',3'-dideoxy-3'-thiacytidine as anti-hepatitis B virus agents

1 reference

12 December 2020

10.2165/00003088-199631020-00005

Identifiers

DOI

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Dimensions Publication ID

27 September 2017

1023838238

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