Wikidata

(Q412742)

English

Hyperforin

chemical compound

In more languages

Statements

chemical structure
Hyperforin-skeletal.png
963 × 1,033; 20 KB
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mass
536.386560144 dalton
1 reference
based on heuristic
inferred from SMILES
canonical SMILES
CCCC(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C
1 reference
stated in
PubChem
isomeric SMILES
CC(C)=CCC[C@]1(C)[C@@H](CC=C(C)C)C[C@@]2(CC=C(C)C)C(=O)[C@]1(C(=O)C(C)C)C(=O)C(CC=C(C)C)=C2O
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found in taxon
Hypericum perforatum
55 references
stated in
Current St John's wort research from mode of action to clinical efficacy
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Treatment with Hypericum perforatum L. does not trigger decreased resistance in Staphylococcus aureus against antibiotics and Hyperforin
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High performance liquid chromatography/electrospray mass spectrometry of Hypericum perforatum extracts
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Identification of the major constituents of Hypericum perforatum by LC/SPE/NMR and/or LC/MS.
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Hypericum perforatum--chemical profiling and quantitative results of St. John's Wort products by an improved high-performance liquid chromatography method
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Improved procedure for the quality control of Hypericum perforatum L.
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Quantitative analysis of the active components and the by-products of eight dry extracts of Hypericum perforatum L. (St John's Wort).
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Fast high-performance liquid chromatographic analysis of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts
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Comparative evaluation of St. John's wort from different Italian regions
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Evaluation of major active components in St. John's Wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation
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Identification by high-performance liquid chromatography–diode array detection–mass spectrometry and quantification by high-performance liquid chromatography–UV absorbance detection of active constituents of Hypericum perforatum
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Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity
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Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models
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The structure of hyperforin
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The content of hypericins and phloroglucinols in Hypericum perforatum L. seedlings at early stage of development
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Hypericum perforatum L. - chemotype without rutin from Italy
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High performance liquid chromatographic analysis of St. John's wort with photodiode array detection.
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Evaluation of chemical stability of St. John's wort commercial extract and some preparations
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Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations
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Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow
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Supercritical extraction of herbs I: Saw Palmetto, St John's Wort, Kava Root, and Echinacea
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Clinical significance of hyperforin for the efficacy of Hypericum extracts on depressive disorders of different severities
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Comparison of German St. John's wort products according to hyperforin and total hypericin content.
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High-Performance Liquid Chromatography On-Line Coupled to High-Field NMR and Mass Spectrometry for Structure Elucidation of Constituents ofHypericum perforatumL.
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Supercritical fluid extraction and high-performance liquid chromatographic determination of phloroglucinols in St. John's Wort (Hypericum perforatum L.).
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Quantitative changes of dianthrones, hyperforin and flavonoids content in the flower ontogenesis of Hypericum perforatum
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Phenolic compounds from Hypericum perforatum
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Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum.
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Effect of acute drought stress and time of harvest on phytochemistry and dry weight of St. John's wort leaves and flowers
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Significance of genetic and environmental aspects in the field cultivation of Hypericum perforatum
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Quantitative phytochemical analyses of six hypericum species growing in slovenia
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Adhyperforin: A Homologue of Hyperforin from Hypericum perforatum
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Analysis and stability of Hyperici oleum
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Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L
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Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility
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Activity profiles of two hyperforin-containing hypericum extracts in behavioral models
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Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG).
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Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers
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Determination of Major Constituents in St. John's Wort Under Different Extraction Conditions
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THE DEVELOPMENT AND EVALUATION OF AN HPLC-DAD METHOD FOR THE ANALYSIS OF THE PHENOLIC FRACTIONS FROMIN VIVOANDIN VITROBIOMASS OFHYPERICUMSPECIES
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Determining hyperforin and hypericin content in eight brands of St. John's wort.
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A Simple and Reliable Semipreparative High-Performance Liquid Chromatography Technique for the Isolation of Marker-Grade Hyperforin from Hypericum perforatum L. Extract
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Simultaneous Determination of the Predominant Hyperforins and Hypericins in St. John's Wort (Hypericum perforatum L.) by Liquid Chromatography
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Determination of St. John's Wort Components in Dietary Supplements and Functional Foods by Liquid Chromatography
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Pharmaceutical quality of hypericum extracts
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Isolation, purity analysis and stability of hyperforin as a standard material from Hypericum perforatum L.
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Ontogenetic Variation Regarding Hypericin and Hyperforin Levels in Four Accessions ofHypericum perforatumL.
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Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines
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Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.
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Biosynthesis of hyperforin in Hypericum perforatum
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Studies on the antioxidative activity of phloroglucinol derivatives isolated from hypericum species
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Bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors
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Pharmaceutical Quality of Hypericum Extracts
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Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts
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Investigations on the Infraspecific Variability of Hypericum perforatum L.
Commons category
Hyperforin
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Identifiers

PubChem CID
441298
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Reaxys registry number
6785663
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HSDB ID
7646
1 reference
stated in
Hazardous Substances Data Bank
HSDB ID
7646
publication date
28 October 2019
title
HYPERFORIN (English)
retrieved
10 May 2021
EC number
601-000-9
1 reference
stated in
ECHA Substance Infocard database
ECHA Substance Infocard ID
100.112.565
retrieved
27 December 2018
title
Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-, (1R,5S,6R,7S)- (English)
quotation
CAS no.: 11079-53-1 (English)
ECHA Substance Infocard ID
100.112.565
1 reference
stated in
ECHA Substance Infocard database
ECHA Substance Infocard ID
100.112.565
retrieved
27 December 2018
title
Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-, (1R,5S,6R,7S)- (English)
quotation
CAS no.: 11079-53-1 (English)
KNApSAcK ID
C00034542
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UNII
RM741E34FP
0 references
NALT ID
46555
0 references
 
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