(Q41371110)

30 September 2017

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title

Pharmacogenetics in pediatrics. Implications for practice (English)

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30 September 2017

Leeder JS

1

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30 September 2017

Kearns GL

series ordinal

2

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30 September 2017

publication date

1 February 1997

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Pediatric Clinics of North America

30 September 2017

published in

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30 September 2017

volume

44

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30 September 2017

issue

1

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30 September 2017

page(s)

55-77

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Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

30 September 2017

cites work

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Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults

7 January 2021

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Altered theophylline pharmacokinetics during acute respiratory viral illness

7 January 2021

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Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions

7 January 2021

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Nomenclature for human CYP2D6 alleles

7 January 2021

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Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity

7 January 2021

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The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

7 January 2021

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Antidepressant drug interactions and the cytochrome P450 system. The role of cytochrome P450 2D6.

7 January 2021

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Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

7 January 2021

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Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in children

7 January 2021

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Drug interactions and the cytochrome P450 system. The role of cytochrome P450 2C19.

7 January 2021

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Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

7 January 2021

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Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.

7 January 2021

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Carbamazepine and carbamazepine-10,11-epoxide serum concentrations in epileptic children

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Biochemistry and molecular biology of the human CYP2C subfamily

7 January 2021

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Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

7 January 2021

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Pharmacogenetic phenotyping and genotyping. Present status and future potential.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

N-acetylation in healthy and diseased children

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Effects of alpha-interferon on theophylline pharmacokinetics and metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

The use of caffeine for enzyme assays: a critical appraisal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Pharmacokinetic studies in paediatric patients. Clinical and ethical considerations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

N-acetyltransferase 2 polymorphism in patients infected with human immunodeficiency virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Hepatic drug clearance in patients with mild cystic fibrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

CYP3A gene expression in human gut epithelium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Alterations in theophylline metabolism during the first year of life

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Measurement of in vivo microsomal epoxide hydrolase activity in white subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Altered patterns of drug metabolism in patients with acquired immunodeficiency syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Cytochrome P450 isozymes and antiepileptic drug interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Cloning, expression and structure of catechol-O-methyltransferase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Genetic differences in drug disposition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Genetic polymorphisms of drug metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Evaluation of a scheme for establishing and maintaining dosage of theophylline in ambulatory patients with chronic asthma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Acetaminophen elimination kinetics in neonates, children, and adults

7 January 2021

1 reference

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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

7 January 2021

1 reference

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Newer antidepressants and the cytochrome P450 system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Thiopurine Methyltransferase in Humans: Development and Tissue Distribution

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

First-pass metabolism of midazolam by the human intestine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Caffeine acetylator phenotyping during maturation in infants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Thiopurine methyltransferase activity in a Korean population sample of children.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Cisapride-induced dysrhythmia in a pediatric patient receiving extracorporeal life support

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Kinetics of carbamazepine and its 10,11‐epoxide metabolite in children

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Mechanisms of unpredictable adverse drug reactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Severe adverse cutaneous reactions to drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Expression of CYP2D6 in developing human liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Nomenclature for N-acetyltransferases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Noninvasive tests of CYP3A enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Identification of an inducible form of cytochrome P-450 in human liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Chloramphenicol in the newborn infant. A physiologic explanation of its toxicity when given in excessive doses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Inhibition of theophylline metabolism by interferon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

The human hepatic cytochromes P450 involved in drug metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Expression of functional cytochrome P4501A1 in human embryonic hepatic tissues during organogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

7 January 2021

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

7 January 2021

Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

7 January 2021

The effect of age, gender, and sexual maturation on the caffeine breath test

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

7 January 2021

Higher activity of polymorphic thiopurine S-methyltransferase in erythrocytes from neonates compared to adults

1 reference

https://api.crossref.org/works/10.1016%2FS0031-3955%2805%2970463-6

7 January 2021

10.1016/S0031-3955(05)70463-6

Identifiers

DOI

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30 September 2017

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