(Q41388134)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28808226%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

title

ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways (English)

1 reference

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27 March 2020

21

1 reference

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27 March 2020

17

Julian Whitelegge

1 reference

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27 March 2020

15

Antoni Ribas

1 reference

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27 March 2020

author name string

Thuc M Le

1

1 reference

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27 March 2020

Soumya Poddar

2

1 reference

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27 March 2020

Joseph R Capri

3

1 reference

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27 March 2020

Evan R Abt

4

1 reference

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27 March 2020

Woosuk Kim

5

1 reference

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27 March 2020

Liu Wei

6

1 reference

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27 March 2020

Nhu T Uong

7

1 reference

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27 March 2020

Chloe M Cheng

8

1 reference

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27 March 2020

Daniel Braas

9

1 reference

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27 March 2020

Mina Nikanjam

10

1 reference

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27 March 2020

Peter Rix

11

1 reference

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27 March 2020

Daria Merkurjev

12

1 reference

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27 March 2020

Jesse Zaretsky

13

1 reference

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27 March 2020

Harley I Kornblum

14

1 reference

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27 March 2020

Harvey R Herschman

16

1 reference

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27 March 2020

Kym F Faull

18

1 reference

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27 March 2020

Timothy R Donahue

19

1 reference

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27 March 2020

Johannes Czernin

20

1 reference

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27 March 2020

language of work or name

English

0 references

publication date

14 August 2017

1 reference

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27 March 2020

published in

Nature Communications

1 reference

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27 March 2020

volume

8

1 reference

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27 March 2020

issue

1

1 reference

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27 March 2020

page(s)

241

1 reference

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Creative Commons Attribution 4.0 International

27 March 2020

copyright license

start time

14 August 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma

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A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors

1 October 2017

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[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity

1 October 2017

1 reference

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A crucial role for ATR in the regulation of deoxycytidine kinase activity

1 October 2017

1 reference

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Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

1 October 2017

1 reference

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Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation.

1 October 2017

1 reference

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Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

1 October 2017

1 reference

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BCR-ABL1 mutation development during first-line treatment with dasatinib or imatinib for chronic myeloid leukemia in chronic phase

1 October 2017

1 reference

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Exploiting replicative stress to treat cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Metabolic pathways promoting cancer cell survival and growth

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

ATM and ATR as therapeutic targets in cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis

1 October 2017

1 reference

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Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies

1 October 2017

1 reference

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Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

ATR activates the S-M checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

How unfinished business from S-phase affects mitosis and beyond

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Targeting ATR in DNA damage response and cancer therapeutics.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair

1 October 2017

1 reference

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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Nucleotide deficiency promotes genomic instability in early stages of cancer development

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Targeting metabolic transformation for cancer therapy.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Maintaining genome stability at the replication fork

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Requirement for deoxycytidine kinase in T and B lymphocyte development.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

New insights into checkpoint kinase 1 in the DNA damage response signaling network

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Principles of cancer therapy: oncogene and non-oncogene addiction

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Global regulation of nucleotide biosynthetic genes by c-Myc

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Structural basis for substrate promiscuity of dCK

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Ribonucleotide reductases

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Gallium compounds as antineoplastic agents

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

ATR and ATM regulate the timing of DNA replication origin firing

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Hydroxyurea Arrests DNA Replication by a Mechanism That Preserves Basal dNTP Pools

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

E2f3 is critical for normal cellular proliferation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

ADA and PNP deficiencies: how it all began

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Interactions between deoxyribonucleotide and DNA synthesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

OASIS: web-based platform for exploring cancer multi-omics data

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5556071

Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones

19 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-017-00221-3

7 January 2021

inferred from DOI database lookup

Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-017-00221-3

7 January 2021

inferred from DOI database lookup

Purine metabolism in human T lymphocytes: role of the purine nucleoside cycle

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-017-00221-3

7 January 2021

inferred from DOI database lookup

High-dose thymidine infusions in patients with leukemia and lymphoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28808226

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41467-017-00221-3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28808226%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28808226%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

PubMed publication ID

28808226

1 reference