(Q37696954)

22 August 2017

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title

Maintaining genome stability at the replication fork (English)

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22 August 2017

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Dana Branzei

1

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Marco Foiani

object named as

Marco Foiani

series ordinal

2

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language of work or name

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1 March 2010

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Nature Reviews Molecular Cell Biology

22 August 2017

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22 August 2017

11

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22 August 2017

208-219

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22 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nrm2852

22 August 2017

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cites work

Flexibility and governance in eukaryotic DNA replication.

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Enigmatic variations: divergent modes of regulating eukaryotic DNA replication

31 March 2020

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DNA replication as a target of the DNA damage checkpoint

31 March 2020

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Replication dynamics of the yeast genome.

31 March 2020

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Mapping of early firing origins on a replication profile of budding yeast

31 March 2020

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Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins.

31 March 2020

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The effect on chromosome stability of deleting replication origins

31 March 2020

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Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress.

31 March 2020

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Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.

31 March 2020

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Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle

31 March 2020

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Replication origins in the eucaryotic chromosome

31 March 2020

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The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes.

31 March 2020

1 reference

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.

31 March 2020

1 reference

Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA.

31 March 2020

1 reference

The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA.

31 March 2020

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Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase.

31 March 2020

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How telomeres are replicated

31 March 2020

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Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants

31 March 2020

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Genome instability: a mechanistic view of its causes and consequences

31 March 2020

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Maintenance of genome stability in Saccharomyces cerevisiae

31 March 2020

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The Mcm2-7 complex has in vitro helicase activity.

31 March 2020

1 reference

Uninterrupted MCM2-7 function required for DNA replication fork progression

31 March 2020

1 reference

Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.

31 March 2020

1 reference

Eukaryotic replicators and associated protein complexes

31 March 2020

1 reference

Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase

31 March 2020

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Getting started: regulating the initiation of DNA replication in yeast

31 March 2020

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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

31 March 2020

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S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

31 March 2020

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DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1.

31 March 2020

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Checkpoint-mediated control of replisome–fork association and signalling in response to replication pausing

31 March 2020

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Topological challenges to DNA replication: conformations at the fork

31 March 2020

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Cellular roles of dna topoisomerases: a molecular perspective

31 March 2020

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Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation

31 March 2020

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Sequences that promote formation of catenated intertwines during termination of DNA replication

31 March 2020

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Replication fork stalling at natural impediments

31 March 2020

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ATR Regulates Fragile Site Stability

31 March 2020

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DNA replication fork pause sites dependent on transcription

31 March 2020

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Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae

31 March 2020

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The organization of replication and transcription

31 March 2020

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DNA knotting caused by head-on collision of transcription and replication

31 March 2020

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Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

31 March 2020

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Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.

31 March 2020

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Instability and decay of the primary structure of DNA

31 March 2020

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DNA structures, repeat expansions and human hereditary disorders.

31 March 2020

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Repeat instability as the basis for human diseases and as a potential target for therapy

31 March 2020

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Trinucleotide Repeat Disorders

31 March 2020

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31 March 2020

Chromosome fragile sites

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Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium

31 March 2020

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DNA rearrangements associated with a transposable element in yeast

31 March 2020

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Double-strand breaks associated with repetitive DNA can reshape the genome

31 March 2020

1 reference

Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites.

31 March 2020

1 reference

Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast

31 March 2020

1 reference

The structure of supercoiled intermediates in DNA replication

31 March 2020

1 reference

Preferential DNA secondary structure mutagenesis in the lagging strand of replication in E. coli

31 March 2020

1 reference

Differential DNA secondary structure-mediated deletion mutation in the leading and lagging strands

31 March 2020

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Association of fragile X syndrome with delayed replication of the FMR1 gene

31 March 2020

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Characterization of a high mobility group 1/2 homolog in yeast

31 March 2020

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Suppression of a DNA polymerase delta mutation by the absence of the high mobility group protein Hmo1 in Saccharomyces cerevisiae.

31 March 2020

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Impairment of replication fork progression mediates RNA polII transcription-associated recombination

31 March 2020

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The replisome uses mRNA as a primer after colliding with RNA polymerase

31 March 2020

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A DNA replication-arrest site RTS1 regulates imprinting by determining the direction of replication at mat1 in S. pombe

31 March 2020

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Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork Barrier

31 March 2020

1 reference

Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart

31 March 2020

1 reference

The involvement of Srs2 in post-replication repair and homologous recombination in fission yeast

31 March 2020

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Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication

31 March 2020

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SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

31 March 2020

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Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p

31 March 2020

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SUMOylation regulates Rad18-mediated template switch

31 March 2020

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Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks

31 March 2020

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A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization

31 March 2020

1 reference

The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair

31 March 2020

1 reference

Closing mitosis: the functions of the Cdc14 phosphatase and its regulation

31 March 2020

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The DNA replication checkpoint response stabilizes stalled replication forks

31 March 2020

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Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

31 March 2020

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Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation

31 March 2020

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Expanded CAG repeats activate the DNA damage checkpoint pathway

31 March 2020

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Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: implications for trinucleotide repeat expansion diseases

31 March 2020

1 reference

Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins

31 March 2020

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Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility

31 March 2020

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Positive torsional strain causes the formation of a four-way junction at replication forks.

31 March 2020

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Topological locking restrains replication fork reversal

31 March 2020

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Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells

31 March 2020

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Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication

31 March 2020

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Mrc1 transduces signals of DNA replication stress to activate Rad53.

31 March 2020

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Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.

31 March 2020

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The checkpoint response to replication stress

31 March 2020

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Large-scale expansions of Friedreich's ataxia GAA repeats in yeast

31 March 2020

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Checkpoint activation regulates mutagenic translesion synthesis

31 March 2020

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The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae

31 March 2020

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Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase

31 March 2020

1 reference

Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions

31 March 2020

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

31 March 2020

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A model for replication repair in mammalian cells

31 March 2020

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Replication fork reactivation downstream of a blocked nascent leading strand.

31 March 2020

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The replication intermediates in Escherichia coli are not the product of DNA processing or uracil excision

31 March 2020

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DNA damage checkpoints are involved in postreplication repair.

31 March 2020

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Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice.

31 March 2020

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Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3 and rad52 mutations

31 March 2020

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The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination

31 March 2020

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Requirement of RAD52 group genes for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

31 March 2020

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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

31 March 2020

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Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

31 March 2020

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Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

31 March 2020

1 reference

Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

31 March 2020

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Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae

31 March 2020

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Involvement of a chromatin remodeling complex in damage tolerance during DNA replication

31 March 2020

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The Bloom's syndrome helicase suppresses crossing over during homologous recombination

31 March 2020

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Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.

31 March 2020

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Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.

31 March 2020

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DNA repeat rearrangements mediated by DnaK-dependent replication fork repair

31 March 2020

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Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome

31 March 2020

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Template Switching: From Replication Fork Repair to Genome Rearrangements

31 March 2020

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A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders

31 March 2020

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Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast

31 March 2020

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Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism.

31 March 2020

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DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses

31 March 2020

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The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair

31 March 2020

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Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

31 March 2020

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Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks

31 March 2020

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Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

31 March 2020

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Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.

31 March 2020

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Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

31 March 2020

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Mechanism of homologous recombination: mediators and helicases take on regulatory functions

31 March 2020

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BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.

31 March 2020

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Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.

31 March 2020

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Remodeling of DNA replication structures by the branch point translocase FANCM

31 March 2020

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The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks

31 March 2020

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The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair

31 March 2020

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Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair

31 March 2020

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Mechanism of replication-coupled DNA interstrand crosslink repair

31 March 2020

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The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair

31 March 2020

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BRCA1 participates in DNA decatenation

31 March 2020

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ATR couples FANCD2 monoubiquitination to the DNA-damage response

31 March 2020

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31 March 2020

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Antitumour drugs impede DNA uncoiling by topoisomerase I

31 March 2020

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Regulation of DNA repair throughout the cell cycle

31 March 2020

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Differential usage of non-homologous end-joining and homologous recombination in double strand break repair

31 March 2020

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DNA damage checkpoints: from initiation to recovery or adaptation

31 March 2020

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Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.

31 March 2020

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DNA topoisomerases: structure, function, and mechanism

31 March 2020

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Concepts in sumoylation: a decade on

31 March 2020

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SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast

31 March 2020

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The amino-terminal TPR domain of Dia2 tethers SCF(Dia2) to the replisome progression complex

31 March 2020

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CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing.

31 March 2020

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Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

31 March 2020

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DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress

31 March 2020

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Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7

31 March 2020

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S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51

31 March 2020

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Defects in DNA ligase I trigger PCNA ubiquitylation at Lys 107.

31 March 2020

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Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system

31 March 2020

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12 December 2020

FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling

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12 December 2020

RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage.

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12 December 2020

Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae

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12 December 2020

FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination.

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12 December 2020

Stable DNA replication: interplay between DNA replication, homologous recombination, and transcription

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12 December 2020

Identifiers

DOI

10.1038/NRM2852

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22 August 2017

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PubMed ID

20177396