(Q41432708)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25684204%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism (English)

1 reference

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29 February 2020

0 references

Evripidis Gavathiotis

10

1 reference

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29 February 2020

John R. Engen

11

1 reference

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29 February 2020

12

Loren D Walensky

1 reference

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29 February 2020

author name string

Lauren A Barclay

1

1 reference

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29 February 2020

Thomas E Wales

2

1 reference

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29 February 2020

Thomas P Garner

3

1 reference

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29 February 2020

Franziska Wachter

4

1 reference

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29 February 2020

Susan Lee

5

1 reference

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29 February 2020

Rachel M Guerra

6

1 reference

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29 February 2020

Michelle L Stewart

7

1 reference

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29 February 2020

Craig R Braun

8

1 reference

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29 February 2020

Gregory H Bird

9

1 reference

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29 February 2020

publication date

12 February 2015

1 reference

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29 February 2020

1 reference

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29 February 2020

volume

57

1 reference

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29 February 2020

issue

5

1 reference

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29 February 2020

page(s)

873-886

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25684204%20AND%20SRC:MED&resulttype=core&format=json

After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

29 February 2020

cites work

1 reference

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1 October 2017

1 reference

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Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): biophysical characterization and functional implications.

1 October 2017

1 reference

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An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

1 October 2017

1 reference

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Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties

1 October 2017

1 reference

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Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor

1 October 2017

1 reference

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Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Direct activation of full-length proapoptotic BAK

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Still embedded together binding to membranes regulates Bcl-2 protein interactions.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

BAX activation is initiated at a novel interaction site

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

A stapled BID BH3 helix directly binds and activates BAX

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Bcl-2 changes conformation to inhibit Bax oligomerization

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

The CCPN data model for NMR spectroscopy: development of a software pipeline

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Solution structure of the antiapoptotic protein bcl-2

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384643

Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS.

11 June 2018

1 reference

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Prevention of ischemic brain injury by treatment with the membrane penetrating apoptosis inhibitor, TAT-BH4.

11 June 2018

1 reference

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Analysis of protein complexes with hydrogen exchange and mass spectrometry.

19 August 2018

1 reference

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Evidence for alpha-helical conformation of an essential N-terminal region in the human Bcl2 protein.

19 August 2018

1 reference

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TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo

19 August 2018

1 reference

12 December 2020

Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

12 December 2020

NMR methods for studying protein-protein interactions involved in translation initiation

1 reference

12 December 2020

Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains

1 reference

12 December 2020

10.1016/J.MOLCEL.2015.01.014

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25684204%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25684204%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

25684204

1 reference