(Q41440111)

30 September 2017

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title

Pharmacokinetic optimisation of cancer chemotherapy. Effect on outcomes (English)

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30 September 2017

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Masson E

1

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PubMed ID

9113440

30 September 2017

Zamboni WC

series ordinal

2

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30 September 2017

1 April 1997

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Clinical Pharmacokinetics

30 September 2017

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30 September 2017

32

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30 September 2017

324-343

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30 September 2017

4

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https://scigraph.springernature.com/pub.10.2165/00003088-199732040-00005

30 September 2017

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Suramin, an active drug for prostate cancer: interim observations in a phase I trial

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Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

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Prolonged administration of oral etoposide in patients with relapsed or refractory small-cell lung cancer: a phase II trial

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6-Mercaptopurine cumulative dose: a critical factor of maintenance therapy in average risk childhood acute lymphoblastic leukemia.

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Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia.

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Effect of Suramin on Human Prostate Cancer Cells in Vitro

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Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate

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Effect of hydration on methotrexate plasma concentrations in children with acute lymphocytic leukemia

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Phase I and pharmacologic study of topotecan in patients with impaired renal function

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High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma

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A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer

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12 December 2020

Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors

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12 December 2020

The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer

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12 December 2020

Current Pharmacological Treatment Approaches to Central Nervous System Leukaemia

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12 December 2020

Changes in the clearance of total and unbound etoposide in patients with liver dysfunction

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12 December 2020

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12 December 2020

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

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Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect

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12 December 2020

Methotrexate pharmacokinetics and prognosis in osteosarcoma.

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12 December 2020

Reduced albumin binding promotes the stability and activity of topotecan in human blood

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12 December 2020

Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor

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Variability in the disposition of intraventricular methotrexate: a proposal for rational dosing

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12 December 2020

Busulfan disposition: the role of therapeutic monitoring in bone marrow transplantation induction regimens

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12 December 2020

Development and validation of a pharmacokinetically based fixed dosing scheme for suramin

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12 December 2020

Clinical pharmacodynamics of continuous infusion topotecan in children: systemic exposure predicts hematologic toxicity

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12 December 2020

Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer

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12 December 2020

Prospective validation of a pharmacologically based dosing scheme for the cis-diamminedichloroplatinum(II) analogue diamminecyclobutanedicarboxylatoplatinum

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12 December 2020

Pharmacokinetic optimisation of anticancer therapy

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12 December 2020

A randomized trial of two dose levels of cyclophosphamide, methotrexate, and fluorouracil chemotherapy for patients with metastatic breast cancer.

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12 December 2020

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12 December 2020

Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia

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12 December 2020

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients

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12 December 2020

Suramin-induced polyneuropathy

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12 December 2020

Prolonged administration of oral etoposide in non-small-cell lung cancer: a phase II trial

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12 December 2020

Phase I and clinical evaluation of a pharmacologically guided regimen of suramin in patients with hormone-refractory prostate cancer

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12 December 2020

Polyglutamation of methotrexate. Is methotrexate a prodrug?

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12 December 2020

Carboplatin pharmacokinetics in children: the development of a pediatric dosing formula. The United Kingdom Children's Cancer Study Group

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12 December 2020

Clinical importance of hepatic cytochrome P450 in drug metabolism

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12 December 2020

Methotrexate and 6-mercaptopurine maintenance therapy for childhood acute lymphoblastic leukemia: dose adjustments by white cell counts or by pharmacokinetic parameters?

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12 December 2020

Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors

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12 December 2020

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12 December 2020

Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation

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12 December 2020

Population study of dihydropyrimidine dehydrogenase in cancer patients

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12 December 2020

Clinical pharmacodynamics of continuous infusion teniposide: systemic exposure as a determinant of response in a phase I trial

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12 December 2020

Applications of dose intensity to problems in chemotherapy of breast and colorectal cancer.

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12 December 2020

Pharmacokinetics of vinorelbine in patients with liver metastases.

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12 December 2020

Charles F. Kettering Prize. P-glycoprotein and resistance to anticancer drugs

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12 December 2020

Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology

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12 December 2020

DNA synthesis in human bone marrow is circadian stage dependent

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12 December 2020

Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials

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12 December 2020

The taxoids: paclitaxel and docetaxel

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12 December 2020

Pharmacokinetics of busulfan: correlation with veno-occlusive disease in patients undergoing bone marrow transplantation

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12 December 2020

Circadian time-dependent response of childhood lymphoblastic leukemia to chemotherapy: a long-term follow-up study of survival

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12 December 2020

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infus

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12 December 2020

Effectiveness of carboplatin, etoposide, and bleomycin combination chemotherapy in good-prognosis metastatic testicular nonseminomatous germ cell tumors

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12 December 2020

Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase

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12 December 2020

The chemotherapy of lymphomas: looking back, moving forward--the Richard and Hinda Rosenthal Foundation award lecture.

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12 December 2020

Clinical relevance of biochemical modulation of 5-fluorouracil

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12 December 2020

Prediction of carboplatin clearance from standard morphological and biological patient characteristics

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12 December 2020

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12 December 2020

Sequences of topotecan and cisplatin: phase I, pharmacologic, and in vitro studies to examine sequence dependence

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12 December 2020

Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis

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12 December 2020

Carboplatin dosage: prospective evaluation of a simple formula based on renal function

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12 December 2020

Clinical pharmacokinetics and pharmacodynamics of anticancer drugs in children

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12 December 2020

Differences in teniposide disposition and pharmacodynamics in patients with newly diagnosed and relapsed acute lymphocytic leukemia

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12 December 2020

Normalisation of anti-cancer drug dosage using body weight and surface area: is it worthwhile? A review of theoretical and practical considerations

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12 December 2020

Noninvasive tests of CYP3A enzymes

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12 December 2020

Drug monitoring of etoposide (VP16-213). Correlation of pharmacokinetic parameters to clinical and biochemical data from patients receiving etoposide

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12 December 2020

Relationships between carboplatin exposure and tumor response and toxicity in patients with ovarian cancer

1 reference

12 December 2020

Relation of systemic exposure to unbound etoposide and hematologic toxicity

1 reference

12 December 2020

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

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12 December 2020

Adaptive control with feedback strategies for suramin dosing.

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12 December 2020

Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy.

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12 December 2020

High-dose methotrexate: is it warranted?

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12 December 2020

Karnofsky memorial lecture. Ode to methotrexate

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12 December 2020

Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients

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12 December 2020

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

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12 December 2020

Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer

1 reference

12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

Suramin: development of a population pharmacokinetic model and its use with intermittent short infusions to control plasma drug concentration in patients with prostate cancer

1 reference

12 December 2020

Etoposide pharmacokinetics in patients with normal and abnormal organ function

1 reference

12 December 2020

Failure of orally administered dipyridamole to enhance the antineoplastic activity of fluorouracil in combination with leucovorin in patients with advanced colorectal cancer: a prospective randomized trial

1 reference

12 December 2020

The effect of prior cisplatin therapy on the pharmacokinetics of high-dose methotrexate

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12 December 2020

Treatment of acute lymphoblastic leukemia. 30 years' experience at St. Jude Children's Research Hospital

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12 December 2020

Can pharmacokinetic and pharmacodynamic studies improve cancer chemotherapy?

1 reference

12 December 2020

Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia

1 reference

12 December 2020

Phase I study of suramin given by intermittent infusion without adaptive control in patients with advanced cancer

1 reference

12 December 2020

10.2165/00003088-199732040-00005

Identifiers

DOI

1 reference

PubMed ID

9113440

Dimensions Publication ID

30 September 2017

0 references

1 reference

PubMed ID

9113440