(Q41587802)

English

Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux.

scientific article published on 30 April 2007

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17471182%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17471182%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

pharmacokinetics

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based on heuristic

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Elizabeth C de Lange

6

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30 December 2019

author name string

D Groenendaal

1

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30 December 2019

J Freijer

2

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30 December 2019

D de Mik

3

1 reference

Europe PubMed Central

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30 December 2019

M R Bouw

4

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30 December 2019

M Danhof

5

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30 December 2019

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publication date

30 April 2007

1 reference

Europe PubMed Central

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30 December 2019

British Journal of Pharmacology

1 reference

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30 December 2019

151

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30 December 2019

5

1 reference

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30 December 2019

701-712

1 reference

Europe PubMed Central

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30 December 2019

Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG.

1 reference

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Midazolam exhibits characteristics of a highly permeable P-glycoprotein substrate.

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Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

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Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

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6 June 2018

Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein

1 reference

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6 June 2018

Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats--pharmacokinetic/pharmacodynamic modelling

1 reference

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6 June 2018

The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice.

1 reference

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6 June 2018

Concentration-effect relationships of morphine and morphine-6 beta-glucuronide in the rat.

1 reference

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6 June 2018

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

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6 June 2018

Quantitative microdialysis under transient conditions

1 reference

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6 June 2018

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

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6 June 2018

The enantioselective glucuronidation of morphine in rats and humans. Evidence for the involvement of more than one UDP-glucuronosyltransferase isoenzyme

1 reference

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6 June 2018

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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6 June 2018

Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration

1 reference

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6 June 2018

High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: application to pharmacokinetic/pharmacodynamic studies in rats

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19 August 2018

Variable modulation of opioid brain uptake by P-glycoprotein in mice

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19 August 2018

Morphine blood-brain barrier transport is influenced by probenecid co-administration

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19 August 2018

Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check

1 reference

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19 August 2018

Pharmacokinetic-pharmacodynamic modelling of morphine transport across the blood-brain barrier as a cause of the antinociceptive effect delay in rats--a microdialysis study.

1 reference

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19 August 2018

The effect of altered cerebral blood flow on the cerebral kinetics of thiopental and propofol in sheep.

1 reference

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19 August 2018

P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014001

19 August 2018

Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014001

19 August 2018

Active transport of fentanyl by the blood-brain barrier.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014001

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Methodological aspects of the use of a calibrator in in vivo microdialysis-further development of the retrodialysis method

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Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats.

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Role of morphine glucuronide metabolites in morphine dependence in the rat.

1 reference

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19 August 2018

Blood-brain barrier permeability to morphine-6-glucuronide is markedly reduced compared with morphine.

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Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine

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Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat

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Development of a sequential linked pharmacokinetic and pharmacodynamic simulation model for ivabradine in healthy volunteers

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A population pharmacokinetic-pharmacodynamic analysis of repeated measures time-to-event pharmacodynamic responses: the antiemetic effect of ondansetron

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Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro

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Pharmacokinetics and pharmacodynamics of morphine-3-glucuronide in rats and its influence on the antinociceptive effect of morphine

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Quantification of effect delay and acute tolerance development to morphine in the rat

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Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method

1 reference

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Identifiers

10.1038/SJ.BJP.0707257

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17471182%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17471182%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

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30 December 2019

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