(Q41692388)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Jörg Lippert

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Mikko Niemi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Andreas Schuppert

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

author name string

Markus Krauss

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Rolf Burghaus

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Stefan Willmann

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Lars Kuepfer

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Linus Görlitz

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

language of work or name

1 reference

11 April 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

published in

In silico pharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

volume

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

page(s)

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

25 February 2020

Bayes' theorem

1 reference

18 June 2022

https://europepmc.org/article/PMC/4230716

inferred from PubMed Central ID database lookup

cites work

A mechanistic, model-based approach to safety assessment in clinical development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Integrating cellular metabolism into a multiscale whole-body model

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Multiscale mechanistic modeling in pharmaceutical research and development

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

A Bayesian population PBPK model for multiroute chloroform exposure

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

SLCO1B1 variants and statin-induced myopathy--a genomewide study

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Translating pharmacogenomics: challenges on the road to the clinic

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Whole-body physiologically based pharmacokinetic models

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Variability and memory of protein levels in human cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

A physiological model for the estimation of the fraction dose absorbed in humans.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Statistical issues in toxicokinetic modeling: a bayesian perspective

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Population pharmacokinetics of propofol: a multicenter study

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Basic concepts of pharmacokinetic/pharmacodynamic (PK/PD) modelling

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Disposition of pravastatin sodium, a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Stochastic Relaxation, Gibbs Distributions, and the Bayesian Restoration of Images

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Diazepam pharamacokinetics from preclinical to phase I using a Bayesian population physiologically based pharmacokinetic model with informative prior distributions in WinBUGS.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

A physiologic model for simulating gastrointestinal flow and drug absorption in rats.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

Physiologically based modeling of the inhalation kinetics of styrene in humans using a bayesian population approach

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230716

SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F2193-9616-1-6

Pharmacogenomics of codeine, morphine, and morphine-6-glucuronide: model-based analysis of the influence of CYP2D6 activity, UGT2B7 activity, renal impairment, and CYP3A4 inhibition.

21 January 2018

1 reference

12 December 2020

Physiology-based pharmacokinetic modeling: ready to be used

1 reference

12 December 2020

The effect of neglecting correlations when propagating uncertainty and estimating the population distribution of risk

1 reference

12 December 2020

Biotransformation of pravastatin sodium in humans

1 reference

12 December 2020

Identifiers

DOI

10.1186/2193-9616-1-6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

25 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

PubMed publication ID

25505651

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505651%20AND%20SRC:MED&resulttype=core&format=json