(Q37820451)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153869%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

review article

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title

Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153869%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153869%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Matthew R Durk

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153869%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

publication date

14 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153869%20AND%20SRC:MED&resulttype=core&format=json

Journal of Pharmacokinetics and Pharmacodynamics

18 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153869%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153869%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153869%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

591-615

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153869%20AND%20SRC:MED&resulttype=core&format=json

Quantitative structure-pharmacokinetics relationships: II. A mechanistically based model to evaluate the relationship between tissue distribution parameters and compound lipophilicity.

18 January 2020

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10928-010-9185-X

Physiologically based pharmacokinetics in drug development and regulatory science: a workshop report (Georgetown University, Washington, DC, May 29-30, 2002).

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10928-010-9185-X

Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessment

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10928-010-9185-X

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

21 January 2018

1 reference

12 December 2020

Sequential first-pass elimination of a metabolite derived from a precursor

1 reference

12 December 2020

Effect of flow on first-pass metabolism of drugs: single pass studies on 4-methylumbelliferone conjugation in the serially perfused rat intestine and liver preparations

1 reference

12 December 2020

Hepatic uptake and metabolism of benzoate: a multiple indicator dilution, perfused rat liver study

1 reference

12 December 2020

Futile cycling between 4-methylumbelliferone and its conjugates in perfused rat liver

1 reference

12 December 2020

Stereoselective pharmacokinetics of ketoprofen and ketoprofen glucuronide in end-stage renal disease: evidence for a 'futile cycle' of elimination

1 reference

12 December 2020

Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption.

1 reference

12 December 2020

Qualitative analysis of the role of metabolites in inhibitory drug-drug interactions: literature evaluation based on the metabolism and transport drug interaction database

1 reference

12 December 2020

Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

1 reference

12 December 2020

An integrated approach to model hepatic drug clearance.

1 reference

12 December 2020

Oral absorption and oxidative metabolism of atrazine in rats evaluated by physiological modeling approaches

1 reference

12 December 2020

Route-dependent metabolism of morphine in the vascularly perfused rat small intestine preparation

1 reference

12 December 2020

Approaches to the assessment of stable and chemically reactive drug metabolites in early clinical trials

1 reference

12 December 2020

Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways

1 reference

12 December 2020

Predicting Cancer Risk from Vinyl Chloride Exposure with a Physiologically Based Pharmacokinetic Model

1 reference

12 December 2020

Physiologically based pharmacokinetic modeling of 1,4-Dioxane in rats, mice, and humans

1 reference

12 December 2020

Whole body pharmacokinetic models

1 reference

12 December 2020

A physiologically based pharmacokinetic model for retinoic acid and its metabolites

1 reference

12 December 2020

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

1 reference

12 December 2020

Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine (ARA-C) deamination in several species.

1 reference

12 December 2020

Effect of diffusional barriers on drug and metabolite kinetics

1 reference

12 December 2020

Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models

1 reference

12 December 2020

Physiologic pharmacokinetic models and interanimal species scaling

1 reference

12 December 2020

Futile cycling of a sulfate conjugate by isolated hepatocytes.

1 reference

12 December 2020

Contribution of trichloroacetic acid to liver tumors observed in perchloroethylene (perc)-exposed mice.

1 reference

12 December 2020

In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: implications for risk assessment

1 reference

12 December 2020

Prediction of in vivo drug clearance from in vitro data. II: potential inter-ethnic differences

1 reference

12 December 2020

Sequestered endoplasmic reticulum space for sequential metabolism of salicylamide. Coupling of hydroxylation and glucuronidation

1 reference

12 December 2020

Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling

1 reference

12 December 2020

Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.

1 reference

12 December 2020

Safety testing of metabolites: Expectations and outcomes.

1 reference

12 December 2020

Presence of a diffusional barrier on metabolite kinetics: enalaprilat as a generated versus preformed metabolite

1 reference

12 December 2020

Interplay of phase II enzymes and transporters in futile cycling: influence of multidrug resistance-associated protein 2-mediated excretion of estradiol 17beta-D-glucuronide and its 3-sulfate metabolite on net sulfation in perfused TR(-) and Wistar

1 reference

12 December 2020

In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane

1 reference

12 December 2020

Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly

1 reference

12 December 2020

Development and specification of physiologically based pharmacokinetic models for use in risk assessment

1 reference

12 December 2020

Physiologically based pharmacokinetic model for cefazolin in rabbits and its preliminary extrapolation to man.

1 reference

12 December 2020

Ethyl acrylate risk assessment with a hybrid computational fluid dynamics and physiologically based nasal dosimetry model

1 reference

12 December 2020

Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

1 reference

12 December 2020

Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vapors

1 reference

12 December 2020

A toxicokinetic study of inhaled ethylene glycol ethyl ether acetate and validation of a physiologically based pharmacokinetic model for rat and human.

1 reference

12 December 2020

Challenges and opportunities with modelling and simulation in drug discovery and drug development

1 reference

12 December 2020

Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle

1 reference

12 December 2020

Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite.

1 reference

12 December 2020

Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation.

1 reference

12 December 2020

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

1 reference

12 December 2020

Nonlinear protein binding and enzyme heterogeneity: effects on hepatic drug removal.

1 reference

12 December 2020

Prediction of intestinal first-pass drug metabolism

1 reference

12 December 2020

Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans

1 reference

12 December 2020

Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques

1 reference

12 December 2020

Clearance concepts in pharmacokinetics

1 reference

12 December 2020

Drug metabolites in safety testing

1 reference

12 December 2020

A review of metabolite kinetics

1 reference

12 December 2020

Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to di-n-butylphthalate: evaluation with a PBPK model.

1 reference

12 December 2020

Futile cycling of estrone sulfate and estrone in the recirculating perfused rat liver preparation.

1 reference

12 December 2020

Disparity in intestine disposition between formed and preformed metabolites and implications: a theoretical study

1 reference

12 December 2020

Dosimetric adjustment factors for methyl methacrylate derived from a steady-state analysis of a physiologically based clearance-extraction model.

1 reference

12 December 2020

Effect of zonal transport and metabolism on hepatic removal: enalapril hydrolysis in zonal, isolated rat hepatocytes in vitro and correlation with perfusion data.

1 reference

12 December 2020

Physiological modeling to understand the impact of enzymes and transporters on drug and metabolite data and bioavailability estimates

1 reference

12 December 2020

A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism.

1 reference

12 December 2020

Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model

1 reference

12 December 2020

Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series).

1 reference

12 December 2020

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

1 reference

12 December 2020

Evaluation of physiologically based pharmacokinetic models for use in risk assessment.

1 reference

12 December 2020

Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

1 reference

12 December 2020

A toxicokinetic study of inhaled ethylene glycol monomethyl ether (2-ME) and validation of a physiologically based pharmacokinetic model for the pregnant rat and human.

1 reference

12 December 2020

A commentary: methods and assumptions in the kinetic estimation of metabolite formation

1 reference

12 December 2020

Development of a physiologically based pharmacokinetic model for ethylene glycol and its metabolite, glycolic Acid, in rats and humans

1 reference

12 December 2020

Physiologically based pharmacokinetic model for digoxin disposition in dogs and its preliminary application to humans

1 reference

12 December 2020

A mechanistic approach for the scaling of clearance in children.

1 reference

12 December 2020

Formed and preformed metabolites: facts and comparisons.

1 reference

12 December 2020

Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach

1 reference

12 December 2020

Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study.

1 reference

12 December 2020

Disposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytes

1 reference

12 December 2020

The application of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling for exploring risk assessment approaches of chemical mixtures

1 reference

12 December 2020

Mechanistic approaches to volume of distribution predictions: understanding the processes.

1 reference

12 December 2020

Physiologically based pharmacokinetics of drug-drug interaction: a study of tolbutamide-sulfonamide interaction in rats.

1 reference

12 December 2020

Interpretation and considerations on the safety evaluation of human drug metabolites

1 reference

12 December 2020

Hepatic conjugation/deconjugation cycling pathways. Computer simulations examining the effect of Michaelis-Menten parameters, enzyme distribution patterns, and a diffusional barrier on metabolite disposition

1 reference

12 December 2020

A physiological model to evaluate drug kinetics in patients with hemorrhagic shock followed by fluid resuscitation. Application to amoxicillin-clavulanate

1 reference

12 December 2020

Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver.

1 reference

12 December 2020

Hepatic modeling of metabolite kinetics in sequential and parallel pathways: salicylamide and gentisamide metabolism in perfused rat liver

1 reference

12 December 2020

Interspecies pharmacokinetic scaling and the Dedrick plots

1 reference

12 December 2020

Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human

1 reference

12 December 2020

Physiologically based pharmacokinetic modeling of chloroethane disposition in mice, rats, and women

1 reference

12 December 2020

10.1007/S10928-010-9185-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153869%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference