(Q37277366)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812018%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

review article

1 reference

title

Formed and preformed metabolites: facts and comparisons (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812018%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812018%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

author name string

Marilyn E Morris

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812018%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Huadong Sun

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812018%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

language of work or name

1 reference

1 October 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812018%20AND%20SRC:MED&resulttype=core&format=json

Journal of Pharmacy and Pharmacology

14 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812018%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

volume

60

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812018%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812018%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

page(s)

1247-1275

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18812018%20AND%20SRC:MED&resulttype=core&format=json

Synthesis of an active hydroxylated glutethimide metabolite and some related analogs with sedative-hypnotic and anticonvulsant properties

14 January 2020

cites work

1 reference

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Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters

21 January 2018

1 reference

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Detection of glutathione conjugates derived from 4-ipomeanol metabolism in bile of rats by liquid chromatography-tandem mass spectrometry

21 January 2018

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Drug metabolites in safety testing

21 January 2018

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Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

21 January 2018

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Clinical Pharmacokinetics of Lignocaine

21 January 2018

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21 January 2018

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Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

21 January 2018

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Pharmacokinetics of valganciclovir and ganciclovir following multiple oral dosages of valganciclovir in HIV- and CMV-seropositive volunteers.

21 January 2018

1 reference

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Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist

21 January 2018

1 reference

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Statistical moment theory in chemical kinetics.

21 January 2018

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Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor

21 January 2018

1 reference

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Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats

21 January 2018

1 reference

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Clinical Pharmacokinetics of N-acetylprocainamide

21 January 2018

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XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkey

21 January 2018

1 reference

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Morphine-6-glucuronide (M6G) for postoperative pain relief

21 January 2018

1 reference

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N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

21 January 2018

1 reference

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Vitamin C and 6-amino-vitamin C conjugates of diclofenac: synthesis and evaluation.

21 January 2018

1 reference

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Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.

21 January 2018

1 reference

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Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Metabolism of capecitabine, an oral fluorouracil prodrug: (19)F NMR studies in animal models and human urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Transport is not rate-limiting in morphine glucuronidation in the single-pass perfused rat liver preparation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine--I. Monooxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine--II. Conjugases

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

The cortisol-cortisone shuttle and the apparent specificity of glucocorticoid and mineralocorticoid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

A peptide prodrug approach for improving bisphosphonate oral absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Sulfation of minoxidil by human liver phenol sulfotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Expression cloning of a mammalian proton-coupled oligopeptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Synthesis of analogs of L-valacyclovir and determination of their substrate activity for the oligopeptide transporter in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Carrier-mediated uptake and excretion of bromosulfophthalein-glutathione in perfused rat liver: a multiple indicator dilution study

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Expression and membrane localization of MCT isoforms along the length of the human intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Uptake of a protein-bound polar compound, acetaminophen sulfate, by perfused rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Identification of zomepirac-S-acyl-glutathione in vitro in incubations with rat hepatocytes and in vivo in rat bile

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Heterogeneous zonal distribution of sulfotransferase isoenzymes in rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Expression cloning of a rat liver Na(+)-independent organic anion transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Intestinal metabolism promotes regional differences in apical uptake of indinavir: coupled effect of P-glycoprotein and cytochrome P450 3A on indinavir membrane permeability in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

An integrated approach to model hepatic drug clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Vascular binding, blood flow, transporter, and enzyme interactions on the processing of digoxin in rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Membrane transporter/receptor-targeted prodrug design: strategies for human and veterinary drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Impact of drug transporter studies on drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Tricyclic antidepressants: Effects on the firing rate of brain noradrenergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Covalent binding of rofecoxib, but not other cyclooxygenase-2 inhibitors, to allysine aldehyde in elastin of human aorta

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

First-pass metabolism of midazolam by the human intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

A review of metabolite kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series).

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

The glutathione S-transferases as a possible detoxification system of rat intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Enhancement of transport of D-melphalan analogue by conjugation with L-glutamate across bovine brain microvessel endothelial cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Interaction of intestinal nucleoside transporter hCNT2 with amino acid ester prodrugs of floxuridine and 2-bromo-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Function of uptake transporters for taurocholate and estradiol 17beta-D-glucuronide in cryopreserved human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Organ clearance concepts: new perspectives on old principles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Primary, secondary, and tertiary metabolite kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5'-deoxy-5-fluorocytidine formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

The metabolism of diclofenac--enzymology and toxicology perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Tissue selective drug delivery utilizing carrier-mediated transport systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Carrier-mediated intestinal transport of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Drug uptake systems in liver and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Effect of sulphasalazine and its active metabolite, 5-amino-salicylic acid, on toxic oxygen metabolite production by neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Mouse liver and kidney carboxylesterase (M-LK) rapidly hydrolyzes antitumor prodrug irinotecan and the N-terminal three quarter sequence determines substrate selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Protein covalent binding of maxipost through a cytochrome P450-mediated ortho-quinone methide intermediate in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001

Active Transport of L-Dopa in the Intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0001