(Q41769247)

English

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus

scientific article published on 17 February 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus (English)

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Matthew D Scharff

11

object named as

Matthew Scharff

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

author name string

Sabrina A Volpi

1

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Jiyoti Verma-Gaur

2

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Rabih Hassan

3

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Zhongliang Ju

4

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Sergio Roa

5

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Sanjukta Chatterjee

6

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Uwe Werling

7

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Harry Hou

8

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Britta Will

9

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Ulrich Steidl

10

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Winfried Edelman

12

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Ann J Feeney

13

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Barbara K Birshtein

14

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Europe PubMed Central

PMC publication ID

9 October 2017

language of work or name

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publication date

17 February 2012

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Europe PubMed Central

PMC publication ID

9 October 2017

Journal of Immunology

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Europe PubMed Central

PMC publication ID

9 October 2017

188

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Europe PubMed Central

PMC publication ID

9 October 2017

6

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

2556-2566

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Interaction between the immunoglobulin heavy chain 3' regulatory region and the IgH transcription unit during B cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

CTCF-binding elements mediate control of V(D)J recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

The IgH locus 3' regulatory region: pulling the strings from behind

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Cohesin mediates chromatin interactions that regulate mammalian β-globin expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Crosstalk between genetic and epigenetic information through cytosine deamination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

A role for the IgH intronic enhancer E mu in enforcing allelic exclusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

CTCF-dependent enhancer-blocking by alternative chromatin loop formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Mechanism of somatic hypermutation: critical analysis of strand biased mutation signatures at A:T and G:C base pairs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

SHMTool: a webserver for comparative analysis of somatic hypermutation datasets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Evidence for physical interaction between the immunoglobulin heavy chain variable region and the 3' regulatory region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Yin Yang 1 is a critical regulator of B-cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

The human major histocompatibility complex class II HLA-DRB1 and HLA-DQA1 genes are separated by a CTCF-binding enhancer-blocking element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Elucidation of IgH intronic enhancer functions via germ-line deletion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

The 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Comparative analysis of human and mouse 3' Igh regulatory regions identifies distinctive structural features

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Deletional analyses reveal an essential role for the hs3b/hs4 IgH 3' enhancer pair in an Ig-secreting but not an earlier-stage B cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Identification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Independent immunoglobulin class-switch events occurring in a single myeloma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Myeloma mutant with a novel 3' flanking region: loss of normal sequence and insertion of repetitive elements leads to decreased transcription but normal processing of the alpha heavy-chain gene products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

6 June 2018

CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

18 August 2018

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

18 August 2018

Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

18 August 2018

Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

18 August 2018

Cutting edge: critical role of inducible costimulator in germinal center reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

3 November 2018

The DNA-Binding Protein CTCF Limits Proximal Vκ Recombination and Restricts κ Enhancer Interactions to the Immunoglobulin κ Light Chain Locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430471

2 December 2018

Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement

1 reference

https://pubmed.ncbi.nlm.nih.gov/22345664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22345664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/22345664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody class switching differs among SJL, C57BL/6 and 129 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22345664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage

1 reference

https://pubmed.ncbi.nlm.nih.gov/22345664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/22345664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.1102763

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

ResearchGate publication ID

0 references

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