(Q41776445)

English

Nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb

scientific article published on 25 July 2008

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

9 October 2017

Nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb (English)

1 reference

Europe PubMed Central

9 October 2017

author name string

David W Good

1

1 reference

Europe PubMed Central

9 October 2017

Thampi George

2

1 reference

Europe PubMed Central

9 October 2017

Bruns A Watts

3

1 reference

Europe PubMed Central

9 October 2017

language of work or name

0 references

publication date

25 July 2008

1 reference

Europe PubMed Central

9 October 2017

number of pages

10

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

9 October 2017

283

1 reference

Europe PubMed Central

9 October 2017

39

1 reference

Europe PubMed Central

9 October 2017

26602-26611

1 reference

Europe PubMed Central

9 October 2017

mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Class IA phosphoinositide 3-kinase isoforms and human tumorigenesis: implications for cancer drug discovery and development

1 reference

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6 June 2018

Regulatory binding partners and complexes of NHE3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Defining the role of mTOR in cancer

1 reference

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6 June 2018

Structural and functional analysis of the Na+/H+ exchanger

1 reference

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6 June 2018

Sirolimus--challenging current perspectives

1 reference

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6 June 2018

Role of the Na/H exchanger NHE1 in cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Modulation of the phosphoinositide 3-kinase signaling pathway alters host response to sepsis, inflammation, and ischemia/reperfusion injury

1 reference

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6 June 2018

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

1 reference

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6 June 2018

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

1 reference

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6 June 2018

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Recent advances in the regulation of the TOR pathway by insulin and nutrients

1 reference

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6 June 2018

PDK1, the master regulator of AGC kinase signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

PI3K and negative regulation of TLR signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

The phosphoinositide 3-kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

The changing face of the Na+/H+ exchanger, NHE1: structure, regulation, and cellular actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Role of S6 phosphorylation and S6 kinase in cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

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6 June 2018

Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

The expanding family of eucaryotic Na(+)/H(+) exchangers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Hyposmolality stimulates apical membrane Na(+)/H(+) exchange and HCO(3)(-) absorption in renal thick ascending limb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

1 reference

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6 June 2018

The role of phosphoinositide 3-kinase lipid products in cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Hypertonicity activates MAP kinases and inhibits HCO-3 absorption via distinct pathways in thick ascending limb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

p160ROCK mediates RhoA activation of Na-H exchange

1 reference

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6 June 2018

Nerve growth factor regulates HCO3- absorption in thick ascending limb: modifying effects of vasopressin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Na+/H+ exchangers of mammalian cells.

1 reference

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6 June 2018

A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange

1 reference

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6 June 2018

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

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6 June 2018

Basolateral membrane Na+/H+ exchange enhances HCO3- absorption in rat medullary thick ascending limb: evidence for functional coupling between basolateral and apical membrane Na+/H+ exchangers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

The thick ascending limb as a site of renal bicarbonate reabsorption.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Inhibition of bicarbonate absorption by peptide hormones and cyclic adenosine monophosphate in rat medullary thick ascending limb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

6 June 2018

Nongenomic regulation by aldosterone of the epithelial NHE3 Na(+)/H(+) exchanger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

18 August 2018

The basolateral NHE1 Na+/H+ exchanger regulates transepithelial HCO3- absorption through actin cytoskeleton remodeling in renal thick ascending limb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

18 August 2018

Transepithelial HCO3- absorption is defective in renal thick ascending limbs from Na+/H+ exchanger NHE1 null mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

18 August 2018

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

18 August 2018

Endosomal recycling of the Na+/H+ exchanger NHE3 isoform is regulated by the phosphatidylinositol 3-kinase pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

18 August 2018

Activation of Na+/H+ exchange by platelet-derived growth factor involves phosphatidylinositol 3'-kinase and phospholipase C gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2546562

18 August 2018

Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolocalization of AE2 anion exchanger in rat kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyposmolality stimulates Na(+)/H(+) exchange and HCO(3)(-) absorption in thick ascending limb via PI 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK mediates inhibition of Na(+)/H(+) exchange and HCO(3)(-) absorption by nerve growth factor in MTAL

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-eluting stents

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apical membrane Na+/H+ exchange in rat medullary thick ascending limb. pH-dependence and inhibition by hyperosmolality

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor inhibits HCO3- absorption in renal thick ascending limb through inhibition of basolateral membrane Na+/H+ exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin II inhibits HCO-3 absorption via a cytochrome P-450-dependent pathway in MTAL

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin and chronic kidney disease: beyond the inhibition of inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aldosterone inhibits apical NHE3 and HCO3- absorption via a nongenomic ERK-dependent pathway in medullary thick ascending limb

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional roles of apical membrane Na+/H+ exchange in rat medullary thick ascending limb

1 reference

https://pubmed.ncbi.nlm.nih.gov/18660503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M803019200

1 reference

Europe PubMed Central

9 October 2017

1 reference

Europe PubMed Central

9 October 2017

1 reference

Europe PubMed Central

9 October 2017

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