(Q41828999)

English

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe

scientific article published on 9 December 2010

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe (English)

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Colleen M. Niswender

9

object named as

Colleen M Niswender

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Craig W. Lindsley

12

object named as

Craig W Lindsley

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

P. Jeffrey Conn

11

object named as

P Jeffrey Conn

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

4

object named as

Hyekyung P Cho

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

6

object named as

Emily Days

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Douglas J Sheffler

3

object named as

Douglas J Sheffler

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

1

object named as

Paul R Reid

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

8

object named as

Carrie K Jones

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

author name string

Thomas M Bridges

2

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

L Michelle Lewis

5

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

J Scott Daniels

7

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

C David Weaver

10

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Michael R Wood

13

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

language of work or name

0 references

publication date

9 December 2010

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Bioorganic & Medicinal Chemistry Letters

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

21

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

9

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

2697-2701

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

The antipsychotic potential of muscarinic allosteric modulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Allosteric modulation of kinases and GPCRs: design principles and structural diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Muscarinic acetylcholine receptors as CNS drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Identification of a family of muscarinic acetylcholine receptor genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Identifiers

10.1016/J.BMCL.2010.12.015

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q41828999&oldid=1928213819"