(Q41846059)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

author name string

Thazha P Prakash

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Mark J Graham

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Jinghua Yu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Rick Carty

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Audrey Low

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Alfred Chappell

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Karsten Schmidt

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Chenguang Zhao

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Mariam Aghajan

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Heather F Murray

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Stan Riney

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Sheri L Booten

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Susan F Murray

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Jeff Crosby

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Walt F Lima

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Shuling Guo

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Brett P Monia

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Eric E Swayze

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Punit P Seth

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

publication date

3 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

published in

Nucleic Acids Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

volume

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

issue

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

page(s)

8796-8807

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

21 March 2020

copyright license

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Clinical pharmacological properties of mipomersen (Kynamro), a second generation antisense inhibitor of apolipoprotein B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Liver as a target for oligonucleotide therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

The asialoglycoprotein receptor: a model for endocytic transport receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

The asialoglycoprotein receptor regulates levels of plasma glycoproteins terminating with sialic acid alpha2,6-galactose

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Synthesis of cluster galactosides with high affinity for the hepatic asialoglycoprotein receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Design and synthesis of novel N-acetylgalactosamine-terminated glycolipids for targeting of lipoproteins to the hepatic asialoglycoprotein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Targeted suppression of an amyloidogenic transthyretin with antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin-related liver disease in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Clinical pharmacokinetics of second generation antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Cellular uptake and intracellular trafficking of oligonucleotides: implications for oligonucleotide pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

Clinical development of an antisense therapy for the treatment of transthyretin-associated polyneuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU531

21 January 2018

Identifiers

DOI

10.1093/NAR/GKU531

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

24992960

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24992960%20AND%20SRC:MED&resulttype=core&format=json