(Q41870228)

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Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study

scientific article published on 15 June 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study (English)

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Europe PubMed Central

PMC publication ID

13 October 2017

D Allan Butterfield

13

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D Allan Butterfield

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Europe PubMed Central

PMC publication ID

13 October 2017

author name string

Ada Fiorini

1

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13 October 2017

Rukhsana Sultana

2

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13 October 2017

Sarah Förster

3

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13 October 2017

Marzia Perluigi

4

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13 October 2017

Giovanna Cenini

5

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13 October 2017

Chiara Cini

6

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13 October 2017

Jian Cai

7

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13 October 2017

Jon B Klein

8

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13 October 2017

Susan A Farr

9

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13 October 2017

Michael L Niehoff

10

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13 October 2017

John E Morley

11

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13 October 2017

Vijaya B Kumar

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13 October 2017

publication date

15 June 2013

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13 October 2017

Free Radical Biology and Medicine

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13 October 2017

65

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13 October 2017

1-14

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Europe PubMed Central

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13 October 2017

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3855183/fullTextXML

based on heuristic

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Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease

1 reference

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The SAMP8 mouse: a model to develop therapeutic interventions for Alzheimer's disease

1 reference

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5 June 2018

The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease

1 reference

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

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Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease

1 reference

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The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease

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Pathways towards and away from Alzheimer's disease

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Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

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Lysosomes and brain aging in mammals

1 reference

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5 June 2018

Proteomic identification of nitrated proteins in Alzheimer's disease brain

1 reference

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5 June 2018

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death

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Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress

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Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain

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Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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Mice lacking both presenilin genes exhibit early embryonic patterning defects

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Studies on aging through analysis of the glucose metabolism related to the ATP--production of the senescence accelerated mouse (SAM)

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Nucleic acid therapeutics: state of the art and future prospects.

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Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

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1 reference

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1 reference

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Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein

1 reference

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Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice

1 reference

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1 reference

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Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

1 reference

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The hydrophobic environment of Met35 of Alzheimer's Abeta(1-42) is important for the neurotoxic and oxidative properties of the peptide.

1 reference

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1 reference

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The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42.

1 reference

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Protein oxidation in the brain in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855183

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Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855183

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Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memory.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855183

18 August 2018

Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down syndrome and Alzheimer's disease brain is downregulated at the mRNA and dysregulated at the protein level.

1 reference

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Regional membrane phospholipid alterations in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855183

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The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

1 reference

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1 reference

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2 December 2018

Proteomic analysis of the brain in Alzheimer’s disease: Molecular phenotype of a complex disease process

1 reference

https://pubmed.ncbi.nlm.nih.gov/23777706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23777706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/23777706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.FREERADBIOMED.2013.06.017

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

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