(Q41904409)

English

Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.

scientific article published on 12 October 2012

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scholarly article

1 reference

Europe PubMed Central

13 October 2017

Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. (English)

1 reference

Europe PubMed Central

13 October 2017

0 references

1

1 reference

Europe PubMed Central

13 October 2017

4

1 reference

Europe PubMed Central

13 October 2017

Graeme Milligan

5

object named as

Graeme Milligan

1 reference

Europe PubMed Central

13 October 2017

author name string

Irina G Tikhonova

2

1 reference

Europe PubMed Central

13 October 2017

Sunil K Pandey

3

1 reference

Europe PubMed Central

13 October 2017

language of work or name

0 references

publication date

12 October 2012

1 reference

Europe PubMed Central

13 October 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

13 October 2017

287

1 reference

Europe PubMed Central

13 October 2017

49

1 reference

Europe PubMed Central

13 October 2017

41195-41209

1 reference

Europe PubMed Central

13 October 2017

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510819

5 June 2018

Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors.

1 reference

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The use of GPCR structures in drug design.

1 reference

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5 June 2018

Lifting the lid on GPCRs: the role of extracellular loops

1 reference

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Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases

1 reference

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The role of G-protein-coupled receptors in mediating the effect of fatty acids on inflammation and insulin sensitivity

1 reference

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5 June 2018

Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator

1 reference

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5 June 2018

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

1 reference

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5 June 2018

Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation

1 reference

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Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

1 reference

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Pathway-specific, species, and sub-type counterscreening for better GPCR hits in high throughput screening

1 reference

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5 June 2018

Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3.

1 reference

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GPCR signaling: understanding the pathway to successful drug discovery.

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The structure and function of G-protein-coupled receptors

1 reference

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X-ray structure breakthroughs in the GPCR transmembrane region

1 reference

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5 June 2018

GPR40: good cop, bad cop?

1 reference

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5 June 2018

Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510819

5 June 2018

International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions

1 reference

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5 June 2018

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

1 reference

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5 June 2018

Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids

1 reference

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5 June 2018

Fatty acid receptors as new therapeutic targets for diabetes

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5 June 2018

Constitutive activity and inverse agonism at the alpha1adrenoceptors

1 reference

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5 June 2018

I want a new drug: G-protein-coupled receptors in drug development

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5 June 2018

Principles: receptor theory in pharmacology

1 reference

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5 June 2018

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

1 reference

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The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

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The druggable genome

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A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

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Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

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Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2.

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1 reference

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12 December 2020

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Identifiers

10.1074/JBC.M112.396259

1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

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