(Q41921732)

14 October 2017

title

Immune checkpoint blockade in infectious diseases (English)

1 reference

14 October 2017

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28990586%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Sharon R. Lewin

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28990586%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

Michelle N Wykes

series ordinal

1

1 reference

14 October 2017

language of work or name

English

0 references

publication date

9 October 2017

1 reference

Nature Reviews Immunology

14 October 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28990586%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28990586%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28990586%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

91-104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28990586%20AND%20SRC:MED&resulttype=core&format=json

Coinhibitory Pathways in Immunotherapy for Cancer

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PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity

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The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology

21 January 2018

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Resistance of regulatory T cells to glucocorticoid-induced [corrected] TNFR family-related protein (GITR) during Plasmodium yoelii infection.

21 January 2018

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Ligation of B and T lymphocyte attenuator prevents the genesis of experimental cerebral malaria

21 January 2018

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21 January 2018

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TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

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Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression

21 January 2018

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PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors

21 January 2018

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The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects

21 January 2018

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PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status.

21 January 2018

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

21 January 2018

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PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

21 January 2018

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CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles

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21 January 2018

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Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.

21 January 2018

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CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals

21 January 2018

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Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.

21 January 2018

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A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors

21 January 2018

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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

21 January 2018

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CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

Programmed death-1 expression on CD4⁺ and CD8⁺ T cells in treated and untreated HIV disease

21 January 2018

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PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals

21 January 2018

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Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy

21 January 2018

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Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation

21 January 2018

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Down-regulation of CTLA-4 by HIV-1 Nef protein

21 January 2018

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Effect of ipilimumab on the HIV reservoir in an HIV-infected individual with metastatic melanoma

21 January 2018

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Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy

21 January 2018

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FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Global strategies are required to cure and eliminate HBV infection.

21 January 2018

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Host-virus interactions in hepatitis B virus infection.

21 January 2018

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The phenotype of hepatitis B virus-specific T cells differ in the liver and blood in chronic hepatitis B virus infection.

21 January 2018

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Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection

21 January 2018

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Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.

21 January 2018

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Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation

21 January 2018

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Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection

21 January 2018

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Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B.

21 January 2018

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Clinical Significance of Dynamics of Programmed Death Ligand-1 Expression on Circulating CD14+ Monocytes and CD19+ B Cells with the Progression of Hepatitis B Virus Infection

21 January 2018

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Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

Hepatic expansion of virus-specific CD8+BTLA+ T cells with regulatory properties in chronic hepatitis B virus infection

21 January 2018

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The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function

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Oscillating CD8(+) T cell effector functions after antigen recognition in the liver.

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PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver.

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The expression of PD-1 ligands and their involvement in regulation of T cell functions in acute and chronic woodchuck hepatitis virus infection

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Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection

21 January 2018

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PD-1 Expression and Cytokine Secretion Profiles of Mycobacterium tuberculosis-Specific CD4+ T-Cell Subsets; Potential Correlates of Containment in HIV-TB Co-Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

KLRG1 and PD-1 expression are increased on T-cells following tuberculosis-treatment and identify cells with different proliferative capacities in BCG-vaccinated adults

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection

21 January 2018

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Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

21 January 2018

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TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection

21 January 2018

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Tuberculosis treatment and drug regimens

21 January 2018

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Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease

21 January 2018

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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

21 January 2018

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

21 January 2018

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

21 January 2018

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PD-1 and its ligands in tolerance and immunity

21 January 2018

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SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Expression of programmed death 1 ligands by murine T cells and APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Tissue expression of PD-L1 mediates peripheral T cell tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production

21 January 2018

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Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Regulation of T cell activation and tolerance by PDL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Management of Adverse Events Following Treatment With Anti-Programmed Death-1 Agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Restoring function in exhausted CD8 T cells during chronic viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

21 January 2018

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The epigenetic landscape of T cell exhaustion.

21 January 2018

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

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https://api.crossref.org/works/10.1038%2FNRI.2017.112

Role of LAG-3 in regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

The TIGIT/CD226 axis regulates human T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Modulation of Treg cells/T effector function by GITR signaling is context-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

A New VISTA on combination therapy for negative checkpoint regulator blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: effect of viremia levels and antiviral treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

A potential new pathway for PD-L1 costimulation of the CD8-T cell response to Listeria monocytogenes infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991909

A randomized controlled trial assessing the effects of raltegravir intensification on endothelial function in treated HIV infection

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991909

Anti-GITR antibodies--potential clinical applications for tumor immunotherapy

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991909

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991909

Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection.

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991909

CD4+ and CD8+ T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991909

Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B

3 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.112

31 March 2020

Identifiers

DOI

10.1038/NRI.2017.112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28990586%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28990586%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference