(Q41927790)

14 October 2017

The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk (English)

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14 October 2017

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5

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14 October 2017

Christian Seitz

1

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14 October 2017

Manuela Hugle

series ordinal

2

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14 October 2017

Silvia Cristofanon

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3

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14 October 2017

Aurélie Tchoghandjian

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4

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14 October 2017

language of work or name

English

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publication date

4 December 2012

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International Journal of Cancer

14 October 2017

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14 October 2017

132

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14 October 2017

11

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14 October 2017

2682-2693

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Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

14 October 2017

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Targeting the extrinsic apoptosis pathway in cancer

21 January 2018

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Targeting mitochondria for cancer therapy

21 January 2018

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Lysosomal membrane permeabilization in cell death

21 January 2018

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Lysosomes and autophagy in cell death control

21 January 2018

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Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies

21 January 2018

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 January 2018

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

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Mammalian autophagy: core molecular machinery and signaling regulation

21 January 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

21 January 2018

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Akt and autophagy cooperate to promote survival of drug-resistant glioma

21 January 2018

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Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy

21 January 2018

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Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma

21 January 2018

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Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis

21 January 2018

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Targeting the phosphoinositide 3-kinase pathway in cancer

21 January 2018

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Activation of Akt predicts poor outcome in neuroblastoma

21 January 2018

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PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis

21 January 2018

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Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma.

21 January 2018

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 January 2018

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Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.

21 January 2018

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

21 January 2018

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Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis.

21 January 2018

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Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine.

21 January 2018

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

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PKB and the mitochondria: AKTing on apoptosis

21 January 2018

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Bcl-2 family members: dual regulators of apoptosis and autophagy

21 January 2018

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Molecular mechanisms of N-acetylcysteine actions

21 January 2018

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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

21 January 2018

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Mutations in PIK3CA are infrequent in neuroblastoma

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.27935

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14 October 2017

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