(Q41936234)

14 October 2017

title

The anticancer functions of RIG-I-like receptors, RIG-I and MDA5, and their applications in cancer therapy (English)

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14 October 2017

Yuanbing Wu

1

1 reference

14 October 2017

Xinqiang Wu

2

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14 October 2017

Longhuo Wu

3

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14 October 2017

Xiangcai Wang

4

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14 October 2017

Zhiping Liu

5

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14 October 2017

publication date

31 August 2017

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14 October 2017

published in

Translational Research

1 reference

Global cancer statistics, 2012

14 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Cancer statistics in China, 2015.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Hallmarks of Cancer: The Next Generation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Immunity, Inflammation, and Cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Adaptive immunity maintains occult cancer in an equilibrium state

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Immunogenic cell death in cancer therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Immunotherapy Comes of Age in Lung Cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Human T cell responses against melanoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Retinoic acid-inducible gene-I-like receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Immune signaling by RIG-I-like receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Innate immune detection of microbial nucleic acids.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

RIG-I-like receptors: cytoplasmic sensors for non-self RNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Induction of immunogenic cell death by targeting RIG-I-like helicases in pancreatic cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

5'-Triphosphate RNA is the ligand for RIG-I

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

TRAIL and Noxa are selectively upregulated in prostate cancer cells downstream of the RIG-I/MAVS signaling pathway by nonreplicating Sendai virus particles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Dose dependent activation of retinoic acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Transfected poly(I:C) activates different dsRNA receptors, leading to apoptosis or immunoadjuvant response in androgen-independent prostate cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Role of interferon regulatory factor 3-mediated apoptosis in the establishment and maintenance of persistent infection by Sendai virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Critical Role of IRF-3 in the Direct Regulation of dsRNA-Induced Retinoic Acid-Inducible Gene-I (RIG-I) Expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Apoptosis induced by mammalian reovirus is beta interferon (IFN) independent and enhanced by IFN regulatory factor 3- and NF-κB-dependent expression of Noxa

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Neurotropic arboviruses induce interferon regulatory factor 3-mediated neuronal responses that are cytoprotective, interferon independent, and inhibited by Western equine encephalitis virus capsid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Intestinal inflammation targets cancer-inducing activity of the microbiota.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

New functions for the matrix metalloproteinases in cancer progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Turning tumors into vaccines: co-opting the innate immune system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Implementing combinatorial immunotherapeutic regimens against cancer: The concept of immunological conditioning

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

The RIG-I/MAVS signaling pathway in cancer cell-selective apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

MDA5 complements TLR3 in suppression of neuroblastoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly(I:C), on human breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Targeted activation of melanoma differentiation-associated protein 5 (MDA5) for immunotherapy of pancreatic carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Application potential of toll-like receptors in cancer immunotherapy: Systematic review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Activation of the MDA-5-IPS-1 Viral Sensing Pathway Induces Cancer Cell Death and Type I IFN-Dependent Antitumor Immunity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

The Interferon Stimulator Mitochondrial Antiviral Signaling Protein Facilitates Cell Death by Disrupting the Mitochondrial Membrane Potential and by Activating Caspases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

5‑FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

Therapeutic potential of adenoviral vectors for delivery of expressed RNAi activators

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2017.08.004

10.1016/J.TRSL.2017.08.004

7 January 2021

Identifiers

DOI

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14 October 2017

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