(Q41988564)

English

Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator

scientific article published on 21 June 2012

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scholarly article

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Europe PubMed Central

PMC publication ID

14 October 2017

Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

transmembrane protein

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cystic fibrosis

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Julie Forman-Kay

13

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Inbal Sela-Culang

9

object named as

Inbal Sela-Culang

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author name string

Rhea P Hudson

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

P Andrew Chong

2

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PMC publication ID

14 October 2017

Irina I Protasevich

3

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Robert Vernon

4

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Europe PubMed Central

PMC publication ID

14 October 2017

Efrat Noy

5

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Hermann Bihler

6

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Jian Li An

7

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Ori Kalid

8

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Inbal Sela-Culang

9

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Martin Mense

10

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Hanoch Senderowitz

11

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14 October 2017

Christie G Brouillette

12

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14 October 2017

language of work or name

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publication date

21 June 2012

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Europe PubMed Central

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14 October 2017

Journal of Biological Chemistry

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14 October 2017

287

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Europe PubMed Central

PMC publication ID

14 October 2017

34

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

28480-28494

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

1 reference

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5 June 2018

NMR View: A computer program for the visualization and analysis of NMR data

1 reference

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5 June 2018

Ivacaftor potentiation of multiple CFTR channels with gating mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

The role of protein conformational fluctuations in allostery, function, and evolution.

1 reference

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5 June 2018

Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation

1 reference

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5 June 2018

Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide‐binding domain 1

1 reference

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5 June 2018

Regulatory insertion removal restores maturation, stability and function of DeltaF508 CFTR

1 reference

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5 June 2018

C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

1 reference

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5 June 2018

Improved side-chain torsion potentials for the Amber ff99SB protein force field

1 reference

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5 June 2018

Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant

1 reference

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5 June 2018

Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry

1 reference

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5 June 2018

NMR evidence for differential phosphorylation-dependent interactions in WT and DeltaF508 CFTR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

1 reference

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5 June 2018

Molecular models of the open and closed states of the whole human CFTR protein

1 reference

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5 June 2018

Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

1 reference

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5 June 2018

In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

Phosphorylation of CFTR by PKA promotes binding of the regulatory domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

MUSCLE: multiple sequence alignment with high accuracy and high throughput

1 reference

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5 June 2018

Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436552

5 June 2018

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

1 reference

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5 June 2018

Cystic fibrosis: a worldwide analysis of CFTR mutations--correlation with incidence data and application to screening

1 reference

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5 June 2018

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain

1 reference

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5 June 2018

Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase

1 reference

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5 June 2018

Phosphorylation site independent single R-domain mutations affect CFTR channel activity.

1 reference

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TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteins

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

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Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

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Identification of revertants for the cystic fibrosis delta F508 mutation using STE6-CFTR chimeras in yeast

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Identification of the cystic fibrosis gene: chromosome walking and jumping

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Identification of the cystic fibrosis gene: genetic analysis

1 reference

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

1 reference

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Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

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NMR spectroscopy to study the dynamics and interactions of CFTR.

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Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure

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Characterization of mutations located in exon 18 of the CFTR gene.

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Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

1 reference

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Limited proteolysis as a probe for arrested conformational maturation of delta F508 CFTR

1 reference

https://pubmed.ncbi.nlm.nih.gov/22722932

12 December 2020

based on heuristic

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Use of an induced fit receptor structure in virtual screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/22722932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.371138

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

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