(Q42631749)

4 November 2017

title

Molecular models of the open and closed states of the whole human CFTR protein (English)

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4 November 2017

Jean-Paul Mornon

1

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4 November 2017

Pierre Lehn

series ordinal

2

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4 November 2017

Isabelle Callebaut

series ordinal

3

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4 November 2017

publication date

26 August 2009

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Cellular and Molecular Life Sciences

4 November 2017

published in

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4 November 2017

volume

66

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4 November 2017

issue

21

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4 November 2017

page(s)

3469-3486

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https://scigraph.springernature.com/pub.10.1007/s00018-009-0133-0

4 November 2017

exact match

0 references

cites work

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

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12 December 2020

Three-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain

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12 December 2020

Ion-binding properties of the ClC chloride selectivity filter

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Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.

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Atomic model of human cystic fibrosis transmembrane conductance regulator: membrane-spanning domains and coupling interfaces

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ABC transporter architecture and regulatory roles of accessory domains

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Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain

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Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

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The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics

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Purification and crystallization of the cystic fibrosis transmembrane conductance regulator (CFTR).

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Domain interdependence in the biosynthetic assembly of CFTR.

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Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore

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Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

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12 December 2020

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

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12 December 2020

Crystal structures of the ATPase subunit of the glucose ABC transporter from Sulfolobus solfataricus: nucleotide-free and nucleotide-bound conformations

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Hydrophobic cluster analysis: an efficient new way to compare and analyse amino acid sequences

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Protein fold recognition using sequence profiles and its application in structural genomics

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Identification of a second blocker binding site at the cytoplasmic mouth of the cystic fibrosis transmembrane conductance regulator chloride channel pore.

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12 December 2020

Phosphorylation of CFTR by PKA promotes binding of the regulatory domain

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Cysteine substitutions reveal dual functions of the amino-terminal tail in cystic fibrosis transmembrane conductance regulator channel gating

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Structure and mechanism of ABC transporter proteins.

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12 December 2020

Disease-associated mutations in the fourth cytoplasmic loop of cystic fibrosis transmembrane conductance regulator compromise biosynthetic processing and chloride channel activity.

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Ion channels versus ion pumps: the principal difference, in principle

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12 December 2020

Gating the selectivity filter in ClC chloride channels

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12 December 2020

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

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12 December 2020

Arg352 is a major determinant of charge selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel

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A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle

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12 December 2020

A generalized analysis of hydrophobic and loop clusters within globular protein sequences

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12 December 2020

Structural changes during ion channel gating

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CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices

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Flexibility in the ABC transporter MsbA: Alternating access with a twist

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12 December 2020

Structural insights into ABC transporter mechanism

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12 December 2020

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

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12 December 2020

Novel residues lining the CFTR chloride channel pore identified by functional modification of introduced cysteines

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12 December 2020

CFTR chloride channel regulation by an interdomain interaction.

1 reference

12 December 2020

Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR.

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12 December 2020

The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.

1 reference

12 December 2020

Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore

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12 December 2020

Comparative protein structure modeling of genes and genomes

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Architecture of the cystic fibrosis transmembrane conductance regulator protein and structural changes associated with phosphorylation and nucleotide binding.

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Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR).

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The ABC protein turned chloride channel whose failure causes cystic fibrosis

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12 December 2020

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

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Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP

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12 December 2020

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12 December 2020

Nucleotide binding domains of human CFTR: a structural classification of critical residues and disease-causing mutations

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12 December 2020

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

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12 December 2020

Degradation of CFTR by the ubiquitin-proteasome pathway

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12 December 2020

Non-pore lining amino acid side chains influence anion selectivity of the human CFTR Cl- channel expressed in mammalian cell lines

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12 December 2020

The ATP-binding cassette family: a structural perspective.

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12 December 2020

Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships.

1 reference

12 December 2020

Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives.

1 reference

12 December 2020

Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis

1 reference

12 December 2020

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

1 reference

12 December 2020

ESPript: analysis of multiple sequence alignments in PostScript

1 reference

12 December 2020

Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore

1 reference

12 December 2020

The closed state of a H+ channel helical bundle combining precise orientational and distance restraints from solid state NMR

1 reference

12 December 2020

Cystic fibrosis as a disease of misprocessing of the cystic fibrosis transmembrane conductance regulator glycoprotein

1 reference

12 December 2020

Crystallographic and single-particle analyses of native- and nucleotide-bound forms of the cystic fibrosis transmembrane conductance regulator (CFTR) protein

1 reference

12 December 2020

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

1 reference

12 December 2020

Novel pore-lining residues in CFTR that govern permeation and open-channel block

1 reference

12 December 2020

10.1007/S00018-009-0133-0

Identifiers

DOI

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4 November 2017

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