(Q42080376)

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Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide (English)

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Carlo Franchini

4

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Michela De Bellis

object named as

Michela De Bellis

2

0 references

object named as

Filomena Corbo

3

0 references

Annamaria De Luca

object named as

Annamaria De Luca

1

0 references

Diana Conte Camerino

object named as

Diana Conte Camerino

8

0 references

author name string

Marilena Muraglia

5

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Alessia Catalano

6

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Alessia Carocci

7

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

publication date

29 July 2011

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Neuromuscular Disorders

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

22

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

1

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

56-65

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Sodium Channel Molecular Conformations and Antiarrhythmic Drug Affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Ion channel pharmacology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Molecular mechanisms of gating and drug block of sodium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Human muscle voltage-gated ion channels and hereditary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Piperazine-like compounds: a new group of designer drugs-of-abuse on the European market

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Therapy in myotonic disorders and in muscle channelopathies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Voltage-gated sodium channels as therapeutic targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Determination of the enantiomeric composition of mexiletine and its four hydroxylated metabolites in urine by enantioselective capillary gas chromatography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Ion-channel defects and aberrant excitability in myotonia and periodic paralysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Distinct local anesthetic affinities in Na+ channel subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

Aminoalkyl structural requirements for interaction of lidocaine with the class I antiarrhythmic drug receptor on rat cardiac myocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

An improved vaseline gap voltage clamp for skeletal muscle fibers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

30 May 2018

A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Tocainide analogues binding to human serum albumin: a HPLAC and circular dichroism study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

New insights into the therapeutic inhibition of voltage-gated sodium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Inhibition of Na(+) current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Structural basis of differences in isoform-specific gating and lidocaine block between cardiac and skeletal muscle sodium channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Synthesis and structure-activity relationships of potential anticonvulsants based on 2-piperidinecarboxylic acid and related pharmacophores

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Inhibition of Na(+) current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314985

17 August 2018

Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/21802953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and Biological Evaluation of Chiral α-Aminoanilides with Central Antinociceptive Activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21802953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of stereospecific binding of type I antiarrhythmic drugs to cardiac sodium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/21802953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/21802953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.NMD.2011.07.001

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

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