(Q42161021)

17 October 2017

title

Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models (English)

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17 October 2017

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photoreceptor protein

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Peter M Quinn

2

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Lucie P Pellissier

object named as

Lucie P Pellissier

1

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Jan Wijnholds

object named as

Jan Wijnholds

8

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John G. Flannery

object named as

John G Flannery

6

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author name string

C Henrique Alves

3

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17 October 2017

Rogier M Vos

4

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17 October 2017

Jan Klooster

5

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17 October 2017

J Alexander Heimel

7

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17 October 2017

publication date

20 February 2015

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17 October 2017

published in

Human Molecular Genetics

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17 October 2017

volume

24

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17 October 2017

issue

11

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17 October 2017

page(s)

3104-3118

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The CRB1 and adherens junction complex proteins in retinal development and maintenance.

17 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Whole exome sequencing identifies CRB1 defect in an unusual maculopathy phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

CRB1 mutations in inherited retinal dystrophies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Safety and efficacy of gene transfer for Leber's congenital amaurosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Effect of gene therapy on visual function in Leber's congenital amaurosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Clinical applications of retinal gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Specific tools for targeting and expression in Müller glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Systemic AAV-9 transduction in mice is influenced by animal age but not by the route of administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

AAV-mediated expression targeting of rod and cone photoreceptors with a human rhodopsin kinase promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Crb apical polarity proteins maintain zebrafish retinal cone mosaics via intercellular binding of their extracellular domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Multiple domains in the Crumbs Homolog 2a (Crb2a) protein are required for regulating rod photoreceptor size

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Immunology of AAV-Mediated Gene Transfer in the Eye

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

Retro-orbital injections in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV062

21 January 2018

Identifiers

DOI

10.1093/HMG/DDV062

1 reference

17 October 2017

1 reference