(Q42170170)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

The production of amyloid beta peptide is a critical requirement for the viability of central neurons (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

author name string

Leigh D Plant

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Ian F Smith

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Hugh A Pearson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

John P Boyle

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

language of work or name

English

0 references

publication date

1 July 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

volume

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

page(s)

5531-5535

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

issue

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

5 November 2019

cites work

1 reference

12 December 2020

Cellular mechanisms of beta-amyloid production and secretion

1 reference

12 December 2020

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

12 December 2020

Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site

1 reference

12 December 2020

Enhancement of (45)Ca(2+) influx and voltage-dependent Ca(2+) channel activity by beta-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta

1 reference

12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

12 December 2020

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

1 reference

12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

12 December 2020

Amyloid beta peptides mediate hypoxic augmentation of Ca(2+) channels.

1 reference

12 December 2020

Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease.

1 reference

12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

12 December 2020

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

12 December 2020

Clearing the brain's amyloid cobwebs

1 reference

12 December 2020

Differential effects of unaggregated and aggregated amyloid beta protein (1-40) on K(+) channel currents in primary cultures of rat cerebellar granule and cortical neurones

1 reference

12 December 2020

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

12 December 2020

Presenilins are not required for A beta 42 production in the early secretory pathway.

1 reference

12 December 2020

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

12 December 2020

Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1

1 reference

12 December 2020

Presenilin-1 mutations alter K+ currents in the human neuroblastoma cell line, SH-SY5Y.

1 reference

12 December 2020

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

1 reference

12 December 2020

In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment

1 reference

12 December 2020

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

12 December 2020

Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity

1 reference

12 December 2020

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

12 December 2020

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

1 reference

12 December 2020

Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.

1 reference

12 December 2020

Mouse cortical neurones lacking APP show normal neurite outgrowth and survival responses in vitro.

1 reference

12 December 2020

10.1523/JNEUROSCI.23-13-05531.2003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843253%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference