(Q42220799)

English

Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene

scientific article published on July 2009

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scholarly article

1 reference

Europe PubMed Central

18 October 2017

Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene (English)

1 reference

Europe PubMed Central

18 October 2017

14

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18 October 2017

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object named as

Tingjun Hou

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Europe PubMed Central

18 October 2017

author name string

Marcia I Dawson

1

1 reference

Europe PubMed Central

18 October 2017

Mao Ye

2

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Europe PubMed Central

18 October 2017

Xihua Cao

3

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Europe PubMed Central

18 October 2017

Lulu Farhana

4

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Europe PubMed Central

18 October 2017

Qiong-Ying Hu

5

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Europe PubMed Central

18 October 2017

Yong Zhao

6

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Europe PubMed Central

18 October 2017

Li Ping Xu

7

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Europe PubMed Central

18 October 2017

Alice Kiselyuk

8

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Europe PubMed Central

18 October 2017

Ricardo G Correa

9

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Europe PubMed Central

18 October 2017

Li Yang

10

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Europe PubMed Central

18 October 2017

John C Reed

12

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Europe PubMed Central

18 October 2017

Pamela Itkin-Ansari

13

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Europe PubMed Central

18 October 2017

Michel F Sanner

15

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18 October 2017

Joseph A Fontana

16

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Europe PubMed Central

18 October 2017

Xiao-Kun Zhang

17

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18 October 2017

publication date

1 July 2009

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18 October 2017

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Europe PubMed Central

18 October 2017

4

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18 October 2017

7

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18 October 2017

1106-1119

1 reference

Europe PubMed Central

18 October 2017

Cytosporone B is an agonist for nuclear orphan receptor Nur77.

1 reference

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1 reference

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1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase

1 reference

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1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines

1 reference

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1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth

1 reference

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Effect of heterodimer partner RXRalpha on PPARgamma activation function-2 helix in solution

1 reference

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1 reference

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Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer management

1 reference

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An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferatio

1 reference

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9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and p

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Bexarotene-induced hypothyroidism: bexarotene stimulates the peripheral metabolism of thyroid hormones.

1 reference

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Discovery of ligands for Nurr1 by combined use of NMR screening with different isotopic and spin-labeling strategies

1 reference

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1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways

1 reference

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The NR4A subgroup: immediate early response genes with pleiotropic physiological roles

1 reference

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1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal ant

1 reference

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Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways

1 reference

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26 October 2017

The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis

1 reference

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Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting

1 reference

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Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031428

26 October 2017

1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031428

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In vivo activation of PPAR target genes by RXR homodimers

1 reference

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Structure-based design of potent retinoid X receptor alpha agonists

1 reference

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Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

1 reference

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Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells.

1 reference

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Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

1 reference

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Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1

1 reference

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The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

1 reference

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Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer

1 reference

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26 October 2017

The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment

1 reference

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Molecular recognition of agonist ligands by RXRs

1 reference

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Phytanic acid, a natural peroxisome proliferator-activated receptor (PPAR) agonist, regulates glucose metabolism in rat primary hepatocytes.

1 reference

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The treatment of cutaneous T-cell lymphoma with a novel retinoid.

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Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma.

1 reference

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Bexarotene ligand pharmaceuticals.

1 reference

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Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain

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Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

1 reference

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Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid

1 reference

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Nur77 transcription activity correlates with its apoptotic function in vivo

1 reference

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Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation

1 reference

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Syntheses and structure-activity relationships of novel retinoid X receptor agonists

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The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

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Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids

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Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids

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Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity

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26 October 2017

Retinoids selective for retinoid X receptor response pathways

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Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses

1 reference

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29 May 2018

Phytanic acid is a retinoid X receptor ligand

1 reference

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Assessment of scaffold hopping efficiency by use of molecular interaction fingerprints

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Identification of a series of highly potent activators of the Nurr1 signaling pathway.

1 reference

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Direct palladium-catalyzed C-2 and C-3 arylation of indoles: a mechanistic rationale for regioselectivity

1 reference

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17 August 2018

Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain

1 reference

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Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain.

1 reference

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17 August 2018

Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis

1 reference

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ET-1 expression and growth inhibition of prostate cancer cells: a retinoid target with novel specificity

1 reference

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17 August 2018

Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19378296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[NGFI-B/nur77 family involved in T-cell apoptosis]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19378296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand selectivity of the peroxisome proliferator-activated receptor alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/19378296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19378296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/19378296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19378296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19378296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800447

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CMDC.200800447

1 reference

Europe PubMed Central

18 October 2017

1 reference

Europe PubMed Central

18 October 2017

1 reference

Europe PubMed Central

18 October 2017

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