(Q42321543)

26 October 2017

A conformational switch regulates the ubiquitin ligase HUWE1. (English)

1 reference

26 October 2017

Sonja Lorenz

5

0 references

author name string

Bodo Sander

1

1 reference

26 October 2017

Wenshan Xu

2

1 reference

26 October 2017

Martin Eilers

3

1 reference

26 October 2017

Nikita Popov

4

1 reference

26 October 2017

language of work or name

English

0 references

publication date

14 February 2017

1 reference

26 October 2017

1 reference

26 October 2017

6

1 reference

describes a project that uses

26 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5308896/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation

26 October 2017

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Absolute Proteome Analysis of Colorectal Mucosa, Adenoma, and Cancer Reveals Drastic Changes in Fatty Acid Metabolism and Plasma Membrane Transporters.

26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

26 October 2017

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ARF tumor suppression in the nucleolus

26 October 2017

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Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

26 October 2017

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26 October 2017

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26 October 2017

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Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

26 October 2017

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Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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Structure-based model of allostery predicts coupling between distant sites

26 October 2017

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26 October 2017

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Structure and function of a HECT domain ubiquitin-binding site

26 October 2017

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Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

26 October 2017

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The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2

26 October 2017

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E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation

26 October 2017

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The ARF tumor suppressor: structure, functions and status in cancer

26 October 2017

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26 October 2017

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26 October 2017

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Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

26 October 2017

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The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates

26 October 2017

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A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities

26 October 2017

1 reference

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Building ubiquitin chains: E2 enzymes at work

26 October 2017

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The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Structure and flexibility within proteins as identified through small angle X-ray scattering

26 October 2017

1 reference

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Phasercrystallographic software

26 October 2017

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Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

26 October 2017

1 reference

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Polyubiquitination by HECT E3s and the determinants of chain type specificity

26 October 2017

1 reference

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Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site

26 October 2017

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The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

26 October 2017

1 reference

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Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

26 October 2017

1 reference

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Inference of macromolecular assemblies from crystalline state

26 October 2017

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Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling

26 October 2017

1 reference

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Divorcing ARF and p53: an unsettled case

26 October 2017

1 reference

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26 October 2017

1 reference

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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

26 October 2017

1 reference

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BH3-ligand regulates access of MCL-1 to its E3 ligase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

26 October 2017

1 reference

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Binding properties and evolution of homodimers in protein-protein interaction networks

26 October 2017

1 reference

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Coot: model-building tools for molecular graphics

26 October 2017

1 reference

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Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

The INK4a/ARF network in tumour suppression

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

p53-independent functions of the p19(ARF) tumor suppressor

26 October 2017

1 reference

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EMBOSS: the European Molecular Biology Open Software Suite

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

26 October 2017

1 reference

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Sequence determinants of E2-E6AP binding affinity and specificity

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

The peripheral subunit-binding domain of the dihydrolipoyl acetyltransferase component of the pyruvate dehydrogenase complex of Bacillus stearothermophilus: preparation and characterization of its binding to the dihydrolipoyl dehydrogenase component

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

The -4 phenylalanine is required for substrate ubiquitination catalyzed by HECT ubiquitin ligases

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

In vitro assembly and recognition of Lys-63 polyubiquitin chains

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308896

Amplification of closed circular DNA in vitro

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554%2FELIFE.21036

PRIMUS: a Windows PC-based system for small-angle scattering data analysis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554%2FELIFE.21036

Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554%2FELIFE.21036

21 January 2018

Identifiers

DOI

10.7554/ELIFE.21036

1 reference

26 October 2017

1 reference

26 October 2017

PubMed publication ID

28193319

1 reference