(Q42359171)

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International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes

scientific article published on August 2008

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scholarly article

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Europe PubMed Central

PMC publication ID

28 October 2017

International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes (English)

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

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author name string

A S Bass

1

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

B Darpo

2

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

A Breidenbach

3

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

K Bruse

4

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

H S Feldman

5

1 reference

Europe PubMed Central

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28 October 2017

D Garnes

6

1 reference

Europe PubMed Central

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28 October 2017

T Hammond

7

1 reference

Europe PubMed Central

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28 October 2017

W Haverkamp

8

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

C January

9

1 reference

Europe PubMed Central

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28 October 2017

J Koerner

10

1 reference

Europe PubMed Central

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28 October 2017

C Lawrence

11

1 reference

Europe PubMed Central

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28 October 2017

D Leishman

12

1 reference

Europe PubMed Central

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28 October 2017

D Roden

13

1 reference

Europe PubMed Central

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28 October 2017

J P Valentin

14

1 reference

Europe PubMed Central

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28 October 2017

M A Vos

15

1 reference

Europe PubMed Central

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28 October 2017

Y-Y Zhou

16

1 reference

Europe PubMed Central

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28 October 2017

T Karluss

17

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Europe PubMed Central

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28 October 2017

P Sager

18

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Europe PubMed Central

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28 October 2017

language of work or name

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publication date

1 August 2008

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28 October 2017

British Journal of Pharmacology

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28 October 2017

154

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Europe PubMed Central

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28 October 2017

7

1 reference

Europe PubMed Central

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28 October 2017

1491-1501

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

The impact of varying autonomic states on the dynamic beat-to-beat QT-RR and QT-TQ interval relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Moving towards better predictors of drug-induced torsades de pointes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Cellular basis of drug-induced torsades de pointes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

In vitro models of proarrhythmia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Guide to Receptors and Channels (GRAC), 2nd edition (2007 Revision).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Differentiation of arrhythmia risk of the antibacterials moxifloxacin, erythromycin, and telithromycin based on analysis of monophasic action potential duration alternans and cardiac instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

The long QT syndrome family of cardiac ion channelopathies: a HuGE review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Risk assessment in drug development for symptomatic indications: a framework for the prospective exclusion of unacceptable cardiovascular risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

QT interval prolongation and arrhythmia: an unbreakable connection?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Long QT syndrome: reduced repolarization reserve and the genetic link

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine-induced torsades de pointes arrhythmias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Clinical trial design to evaluate the effects of drugs on cardiac repolarization: current state of the art.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

HERG block, QT liability and sudden cardiac death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Nonclinical proarrhythmia models: predicting Torsades de Pointes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Predictive in silico modeling for hERG channel blockers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Antiarrhythmic and proarrhythmic properties of QT-prolonging antianginal drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Oral erythromycin and the risk of sudden death from cardiac causes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Spontaneous adverse event reports of serious ventricular arrhythmias, QT prolongation, syncope, and sudden death in patients treated with cisapride

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

Arterial hemodynamics during head-up tilt in conscious dogs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

29 May 2018

ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

QT PRODACT: inter-facility variability in electrocardiographic and hemodynamic parameters in conscious dogs and monkeys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

QT prolongation modifies dynamic restitution and hysteresis of the beat-to-beat QT-TQ interval relationship during normal sinus rhythm under varying states of repolarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

A new method to calculate the beat-to-beat instability of QT duration in drug-induced long QT in anesthetized dogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

Modulation of QT interval during autonomic nervous system blockade in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

Influence of age, the autonomic nervous system and anxiety on QT-interval variability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

Problems of heart rate correction in assessment of drug-induced QT interval prolongation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

A rat model for predicting orthostatic hypotension during acute and chronic antihypertensive drug therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492102

17 August 2018

Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern

1 reference

https://pubmed.ncbi.nlm.nih.gov/18663380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisapride and fatal arrhythmia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18663380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of autonomic tone on QT interval duration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18663380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationships between heart rate and heart rate variability: study in conscious rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18663380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The risk of serious cardiac arrhythmias among cisapride users in the United Kingdom and Canada

1 reference

https://pubmed.ncbi.nlm.nih.gov/18663380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-cardiac QTc-prolonging drugs and the risk of sudden cardiac death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18663380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Within-subject electrocardiographic differences at equal heart rates: role of the autonomic nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18663380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

1 reference

https://pubmed.ncbi.nlm.nih.gov/18663380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calmodulin antagonist W-7 prevents sparfloxacin-induced early afterdepolarizations (EADs) in isolated rabbit purkinje fibers: importance of beat-to-beat instability of the repolarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/18663380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WITHDRAWN: Sex differences in the expression of sodium/calcium exchanger influence the arrhythmia phenotype in the long QT syndrome type 2

1 reference

https://api.crossref.org/works/10.1038%2FBJP.2008.279

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/BJP.2008.279

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

ResearchGate publication ID

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