(Q42363315)

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Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis.

scientific article published on 10 October 2016

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25 March 2020

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis (English)

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25 March 2020

rheumatoid arthritis

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Philipp J Hohensinner

3

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25 March 2020

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25 March 2020

Cornelia Weyand

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Cornelia M Weyand

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25 March 2020

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Yinyin Li

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25 March 2020

Yi Shen

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25 March 2020

Jihang Ju

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25 March 2020

Stuart B Goodman

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25 March 2020

Hui Zhang

7

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25 March 2020

Jörg J Goronzy

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25 March 2020

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11 October 2016

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25 March 2020

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25 March 2020

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25 March 2020

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25 March 2020

903-916

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25 March 2020

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

1 reference

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29 May 2018

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

1 reference

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29 May 2018

Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis.

1 reference

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29 May 2018

Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model

1 reference

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Genomic integrity and the ageing brain

1 reference

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Switching between Epigenetic States at Pericentromeric Heterochromatin

1 reference

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29 May 2018

Forging a signature of in vivo senescence

1 reference

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Long-lasting stem cell-like memory CD8+ T cells with a naïve-like profile upon yellow fever vaccination

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Constitutive heterochromatin formation and transcription in mammals

1 reference

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Stable cellular senescence is associated with persistent DDR activation

1 reference

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Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

1 reference

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Geriatric muscle stem cells switch reversible quiescence into senescence.

1 reference

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29 May 2018

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

1 reference

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29 May 2018

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

T-cell aging in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

The hallmarks of aging

1 reference

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29 May 2018

Understanding immunosenescence to improve responses to vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

T cell replicative senescence in human aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

1 reference

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29 May 2018

Shelterin complex and associated factors at human telomeres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

The MRE11 complex: starting from the ends.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

1 reference

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29 May 2018

DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis

1 reference

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29 May 2018

The MRN complex in double-strand break repair and telomere maintenance

1 reference

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29 May 2018

p53-independent induction of G1 arrest and p21WAF1/CIP1 expression by ascofuranone, an isoprenoid antibiotic, through downregulation of c-Myc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

CD57+ T lymphocytes and functional immune deficiency.

1 reference

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29 May 2018

Rejuvenating the immune system in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

The mre11 complex and the response to dysfunctional telomeres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5123765

29 May 2018

Telomerase insufficiency in rheumatoid arthritis

1 reference

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29 May 2018

Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.

1 reference

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Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

1 reference

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29 May 2018

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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12 December 2020

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Homeostatic control of T-cell generation in neonates

1 reference

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12 December 2020

based on heuristic

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1 reference

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1 reference

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based on heuristic

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Identifiers

10.1016/J.IMMUNI.2016.09.013

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25 March 2020

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25 March 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27742546%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

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